Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons

Bioorganic & Medicinal Chemistry Letters
Yoshiyasu FukuyamaYasuhide Mitsumoto

Abstract

Honokiol, a main biphenyl neolignan of the traditional crude medicine, Magnoliae cortex, was found to show neurotrophic activity on the cultures of rat cortical neurons at concentration from 0.1 to 10 microM. In the cortical neurons cultured in serum-free medium supplemented with B27, honokiol could promote neurite outgrowth. In addition, the survival and growth of neurons were significantly enhanced by adding honokiol to the primary cultures in serum-free medium supplemented with N2. Its neurotrophic activity was comparable to 40 ng mL(-1) of bFGF at concentration of 10 microM.

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Citations

Sep 4, 2010·Journal of Fluorescence·Hongmei LiYuzhu Hu
Jan 21, 2012·Journal of Natural Medicines·Shinichi HaradaShogo Tokuyama
Apr 28, 2004·Bioorganic & Medicinal Chemistry Letters·Tomoyuki EsumiYoshiyasu Fukuyama
Aug 19, 2003·European Journal of Pharmacology·Haifeng ZhaiYoshiyasu Fukuyama
Mar 28, 2003·Bioorganic & Medicinal Chemistry·Hironobu TakahashiYoshiyasu Fukuyama
Aug 7, 2013·BMC Complementary and Alternative Medicine·Oraphan WanakhachornkraiMayuree H Tantisira
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Nobuaki MatsuiMasaaki Akagi
Jul 8, 2010·Biological & Pharmaceutical Bulletin·Cha-Gyun JungMakoto Michikawa
Jul 5, 2003·Chemical & Pharmaceutical Bulletin·Yushan LiYasushi Ohizumi
Jan 7, 2005·Chemical & Pharmaceutical Bulletin·Yoshiyasu FukuyamaKenichi Harada
Jul 2, 2011·Chemical & Pharmaceutical Bulletin·Miwa KuboYoshiyasu Fukuyama
Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Hideyuki ItoTsutomu Hatano
Jun 16, 2005·Neuro-Signals·Chihiro TohdaKatsuko Komatsu
Apr 7, 2012·Journal of Pharmaceutical and Biomedical Analysis·Zhengjun Cheng
Dec 2, 2015·Regulatory Toxicology and Pharmacology : RTP·Qianqian ZhangShizhong Chen
Feb 1, 2011·Pharmacology & Therapeutics·Young-Jung LeeJin Tae Hong
Apr 25, 2006·European Journal of Pharmacology·Yi-Ruu LinMing-Huan Chan
Dec 8, 2014·Regulatory Toxicology and Pharmacology : RTP·Qianqian ZhangShizhong Chen
May 3, 2007·Chemical & Pharmaceutical Bulletin·Biswanath DindaYoshihiro Harigaya
Apr 19, 2013·Free Radical Research·C Guerra-AraizaH Salgado-Ceballos
May 12, 2020·Frontiers in Chemistry·Kenichi HaradaYoshiyasu Fukuyama
Jul 10, 2020·Journal of Natural Medicines·Yoshiyasu FukuyamaKenichi Harada
Dec 1, 2004·Journal of Natural Products·Yoshiyasu FukuyamaTomoyuki Esumi

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