PMID: 8960986Oct 1, 1996Paper

Neurotrophic effects of transferrin on embryonic chick brain and neural retinal cell cultures

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
A BruininkF Birchler

Abstract

The viability and differentiation promoting effects of various transferrins [iron-saturated (holo) and iron-depleted (apo) human and chick ovo (conalbumin)-transferrins, and bovine apo-transferrin] were studied, using serum-free, flat-sedimented cell cultures of embryonic chick brain and neural retina. The effects of transferrin (Tf) on the cell cultures depended on the type of Tf used and the parameter measured. Significant differences between brain and neural retina cultures in the effects of apo-ovoTf and iron [supplemented as ammonium-iron (III) citrate] were detected. Maximal levels of mitochondrial activity were observed in the presence of 2 mg/l apo-ovoTf in neural retina cell cultures. In brain cell cultures, 40 mg ovoTf/l were needed to achieve maximal levels. In brain, but not in neural, retina cell cultures ovoTf and optimal concentrations of Fe3+ exhibited similar effects on biochemical parameters of cell function and differentiation. Although, in the absence of ovoTf, neuronal outgrowth on areas not covered by glial cells was inhibited in both cell cultures, the differences were more prominent in neural retina cell cultures. Our data strongly suggest that Tf plays a key role in processes not connected directly with...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J E Bottenstein, G H Sato
Dec 1, 1979·European Journal of Immunology·M L Dillner-CenterlindP Perlmann
Oct 1, 1992·Biological Trace Element Research·J S StarreveldH G van Eijk
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S T KunitakeJ P Kane
Oct 11, 1991·Brain Research·A G HyndmanJ A Connor
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N X QianE Englesberg
Mar 1, 1991·Journal of Neuroscience Research·I Barakat-WalterG Labourdette
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Bruinink, P Reiser
Jan 1, 1991·Archives of Toxicology·A BruininkF Riesen
Mar 1, 1986·Journal of Cellular Physiology·T Shimo-OkaE Ozawa
Jan 1, 1986·Journal of Neuroscience Research·C Stamatos, R E Fine
Aug 1, 1986·Journal of Cellular Physiology·R C PenhallowR C Woodworth
Jan 1, 1988·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·L M Sorokin, E H Morgan
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y AizenmanJ de Vellis
Jan 30, 1987·Biochemical and Biophysical Research Communications·S FurukawaK Hayashi
Apr 1, 1985·Cell Differentiation·R L BeachB W Festoff
Feb 1, 1982·European Journal of Biochemistry·J WilliamsK A Kuhn
Sep 1, 1982·In Vitro·W L AndersonT B Tomasi
Jan 1, 1993·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·H KohnoR Tokunaga
Aug 1, 1993·International Journal of Biological Macromolecules·S Q LiuY Imanishi
Jul 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A BruininkG Zbinden
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Jan 29, 2000·Brain Research. Developmental Brain Research·B BauduinB Boilly
Feb 15, 2005·Drug Discovery Today·Peter T GommeJoseph Bertolini
Sep 10, 2010·Experimental Diabetes Research·Andreea CiudinRafael Simó
Dec 9, 2008·Experimental Eye Research·M GoralskaM C McGahan
Mar 1, 2003·Nutritional Neuroscience·Jacob W VanLandingham, Cathy W Levenson
May 16, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ana PenezićOlgica Nedić
Jun 11, 2018·Journal of Neuroinflammation·Jing SunStanislava Pankratova
Aug 23, 2011·Biochimica Et Biophysica Acta·Francesco GiansantiGiovanni Antonini

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