Neurotrophic factors and neuro-muscular disease: II. GDNF, other neurotrophic factors, and future directions

Muscle & Nerve
Hiroshi Mitsumoto, K Tsuzaka


This is the second of two reviews in which we discuss the essential aspects of neurotrophic factor neurobiology, the characteristics of each neurotrophic factor, and their clinical relevance to neuromuscular diseases. The previous paper reviewed the neurotrophin family and neuropoietic cytokines. In the present article, we focus on the GDNF family and other neurotrophic factors and then consider future approaches that may be utilized in neurotrophic factor treatment.


Aug 16, 2006·Neuro-degenerative Diseases·Eva Ekestern
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Aug 3, 2011·Expert Opinion on Emerging Drugs·Ali Aamer Habib, Hiroshi Mitsumoto
Apr 10, 2016·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Jun 18, 2002·Journal of Neurochemistry·Ralph W KunclS Patricia Becerra
Nov 25, 2003·Journal of Applied Physiology·Tanguy MarquestePatrick Decherchi


Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS Squinto
Jan 1, 1992·Progress in Growth Factor Research·N Y Ip, G D Yancopoulos
May 15, 1992·Annals of Internal Medicine·D LeRoithM M Rechler
Oct 23, 1992·Science·T KishimotoT Taga
Jul 5, 1991·Science·S DavisG D Yancopoulos
Nov 1, 1991·The Journal of Cell Biology·M YaarB A Gilchrest
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Yamamori
Jan 1, 1991·Journal of Cell Science. Supplement·M SendtnerH Thoenen
May 1, 1991·Journal of Cellular Biochemistry·D J Hilton, N M Gough
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 1, 1991·Annual Review of Physiology·J R FloriniK A Magri
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Aug 1, 1988·Trends in Neurosciences·Y A Barde
Jul 1, 1989·Trends in Neurosciences·R W Oppenheim
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·G D Braunstein, A L Reviczky
Sep 4, 1987·Science·R Levi-Montalcini

Related Concepts

GDNF gene
Neurotrophic factor
BDNF gene
Neurotrophin Binding
Neurite Outgrowth Factors
Muscular Atrophy
Neuromuscular Diseases

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.