Neurotrophic factors and the pathophysiology of schizophrenic psychoses

European Psychiatry : the Journal of the Association of European Psychiatrists
N Durany, J Thome

Abstract

The aim of this review is to summarize the present state of findings on altered neurotrophic factor levels in schizophrenic psychoses, on variations in genes coding for neurotrophic factors, and on the effect of antipsychotic drugs on the expression level of neurotrophic factors. This is a conceptual paper that aims to establish the link between the neuromaldevelopment theory of schizophrenia and neurotrophic factors. An extensive literature review has been done using the Pub Med database, a service of the National Library of Medicine, which includes over 14 million citations for biomedical articles back to the 1950s. The majority of studies discussed in this review support the notion of alterations of neurotrophic factors at the protein and gene level, respectively, and support the hypothesis that these alterations could, at least partially, explain some of the morphological, cytoarchitectural and neurobiochemical abnormalities found in the brain of schizophrenic patients. However, the results are not always conclusive and the clinical significance of these alterations is not fully understood. It is, thus, important to further neurotrophic factor research in order to better understand the etiopathogenesis of schizophrenic psyc...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K SudaH Thoenen
May 1, 1991·Trends in Neurosciences·H Thoenen
Jan 1, 1991·Schizophrenia Bulletin·F M BenesE D Bird
May 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P Jones, R M Murray
Oct 1, 1991·Archives of General Psychiatry·T L JerniganD L Braff
Jul 1, 1991·Archives of General Psychiatry·S E ArnoldA R Damasio
Dec 1, 1990·Current Opinion in Cell Biology·J A Wagner, S K Kostyk
Jan 1, 1989·Journal of Neural Transmission·J KornhuberH Beckmann
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Jun 1, 1989·Neuron·Y A Barde
Jan 1, 1986·Journal of Neural Transmission·H Jakob, H Beckmann
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
Aug 26, 1995·Lancet·D R Weinberger
Oct 27, 1995·Science·H Thoenen
Jul 1, 1995·Trends in Neurosciences·M V Chao, B L Hempstead
Oct 1, 1995·Archives of General Psychiatry·G TsaiJ T Coyle
Aug 1, 1995·Schizophrenia Research·D R Weinberger, B K Lipska
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·C G WinterD Hirsh
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Jun 5, 1995·The Journal of Comparative Neurology·Y MuragakiV M Lee
Sep 9, 1995·Lancet·P McGuffinA E Farmer
May 1, 1995·The American Journal of Psychiatry·S E ArnoldJ Q Trojanowski
Apr 17, 1995·Biochemical and Biophysical Research Communications·M Hattori, S Nanko
Sep 1, 1994·Brain Research. Molecular Brain Research·A J MacLennanD C Lado
Mar 1, 1995·The American Journal of Psychiatry·J Corey-BloomD V Jeste
Nov 1, 1994·The European Journal of Neuroscience·H R Widmer, F Hefti
Mar 21, 1994·Brain Research·B Cheng, M P Mattson
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·G P Reynolds
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J S O'BrienY Kishimoto
Aug 1, 1994·Nature Genetics·A F Wright, A D Carothers
Jun 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·K MuraseK Hayashi
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·D O Clary, L F Reichardt

❮ Previous
Next ❯

Citations

Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agnieszka Basta-KaimWładysław Lasoń
Jun 24, 2010·International Clinical Psychopharmacology·Ana González-PintoCarlos Matute
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shuji Iritani
Mar 13, 2012·Pharmacological Reviews·Anita E Autry, Lisa M Monteggia
Jan 26, 2012·Psychopharmacology·Xiang Yang ZhangThomas R Kosten
Jul 28, 2010·Psychopharmacology·Xiang Yang ZhangThomas R Kosten
Aug 22, 2014·Acta Neuropsychiatrica·Noortje W A van de KerkhofWillem M A Verhoeven
Sep 24, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Songhee JeonYong Sik Kim
Jan 3, 2016·Neuroscience Letters·Mehmet GüneşAytekin Sir
Jun 16, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jung Goo LeeYoung Hoon Kim
Sep 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mei Hong XiuXiang Yang Zhang
Apr 20, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Qing-Rong TanZhang-Jin Zhang
Apr 17, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco AngelucciAleksander A Mathé
Aug 9, 2011·Autism Research : Official Journal of the International Society for Autism Research·B Crespi
Oct 20, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Heather C WhalleyStephen M Lawrie
Jun 9, 2005·Biological Psychiatry·Yogesh DwivediRobert R Conley
Jul 11, 2006·Schizophrenia Research·Aitor PalominoCarlos Matute
Mar 21, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nico J M van BeverenDurk Fekkes
Sep 16, 2014·Psychiatry Research·Alicia Valiente-GómezMiguel Bernardo Arroyo
Feb 2, 2011·Brain Research·Rachel A Hill, Maarten van den Buuse
Mar 9, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Claudio TomaBru Cormand
Jun 21, 2015·Neuroscience and Biobehavioral Reviews·Juan C LezaMiguel Bernardo
Jan 24, 2015·The International Journal of Neuropsychopharmacology·Wolfgang StrubeAlkomiet Hasan
Dec 8, 2010·Neurochemistry International·Ling ZhangChunli Zhao
Aug 16, 2014·Behavioural Brain Research·Ashley Jayne SkilleterThomas Wesley Weickert
Feb 15, 2015·The International Journal of Biochemistry & Cell Biology·Janice Hiu-Chor Plani-LamYou-Qiang Song
Mar 13, 2015·Frontiers in Psychiatry·James N Samsom, Albert H C Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here