Neurotrophic factors: from molecule to man

Trends in Neurosciences
R M LindsayP S DiStefano

Abstract

Recent advances in the understanding of the physiological role of nerve growth factor (NGF) have raised the question of whether neurotrophic factors might have clinical potential in the treatment of neurodegenerative disease or nerve trauma. Although NGF was first characterized as a target-derived survival factor for developing sympathetic and sensory neurons, it is now clear that it plays an important role in the maintenance and regeneration of mature peripheral neurons. However, the highly restricted specificity of NGF for sympathetic neurons, subpopulations of neural-crest-derived sensory neurons, and striatal and basal forebrain cholinergic neurons has, for almost two decades, stimulated the search for other neurotrophic factors that might act on the many classes of neurons that do not respond to NGF. In this article, the biology of the recently discovered NGF-related family of neurotrophic factors and ciliary neurotrophic factor and their receptors are reviewed, especially in the context of the therapeutic potential of these factors in the treatment of neurological disorders of the CNS.

References

Sep 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·C F BoltonR M Lindsay
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C A AltarC Hyman
May 1, 1991·Trends in Neurosciences·H Thoenen
Sep 30, 1987·Biochemical and Biophysical Research Communications·S FurukawaK Hayashi
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L R WilliamsF H Gage
Jun 1, 1994·The European Journal of Neuroscience·L LärkforsR F Alderson
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Hagg, S Varon
Jan 1, 1993·The European Journal of Neuroscience·N Y IpJ S Rudge

❮ Previous
Next ❯

Citations

Jun 10, 1996·The Journal of Comparative Neurology·E Y ChenJ H Kordower
Aug 25, 1997·The Journal of Comparative Neurology·S SarramM R Byers
Apr 15, 1996·Journal of Neuroscience Research·A D ZurnP Aebischer
May 15, 1997·Journal of Neuroscience Research·M J SchaafE Vreugdenhil
Jul 1, 1997·Journal of Neuroscience Research·H Kamiguchi, V Lemmon
Oct 20, 1998·Journal of Neuroscience Research·Z GuJ R Perez-Polo
Feb 11, 1999·Journal of Neuroscience Research·F M LongoB F Sisken
Aug 9, 2001·Journal of Neuroscience Research·K NakajimaT Kurihara
Mar 1, 1995·Journal of Neuroscience Research·F ZhangW G Tatton
Mar 1, 1996·Protein Science : a Publication of the Protein Society·M GuoK E Neet
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Feb 11, 2011·Psychopharmacology·Montserrat Serra-MillàsCristóbal Gastó
Jan 3, 2012·Rheumatology International·Boya NugrahaChristoph Gutenbrunner
Nov 26, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hironori YokoyamaTsutomu Araki
Oct 20, 2009·Cellular and Molecular Neurobiology·Hiroyuki IchikawaTomosada Sugimoto
Aug 15, 2013·Journal of Molecular Neuroscience : MN·Karamkolly R RekhaRamu Inmozhi Sivakamasundari
Aug 31, 1995·Mechanisms of Ageing and Development·J M TorresJ A Vega
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong
Apr 18, 1995·Brain Research. Developmental Brain Research·T KuboH Hatanaka
Feb 26, 1996·Brain Research. Developmental Brain Research·Y AbiruH Hatanaka
Nov 1, 1994·Trends in Neurosciences·O LindvallM Kokaia
Nov 1, 1995·Trends in Neurosciences·H M Schätzl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.