PMID: 8594213Oct 1, 1995Paper

Neurotrophic factors in central nervous system trauma

Journal of Neurotrauma
I Mocchetti, J R Wrathall

Abstract

Although regeneration of injured neurons does not occur after trauma in the central nervous system (CNS), there is often significant recovery of functional capacity with time. Little is currently known about the molecular basis for such recovery, but the increased trophic activity in injured CNS tissue and the known properties of neurotrophic factors in neuronal growth and maintenance suggest that these polypeptides are probably involved in recovery of function. Members of the neurotrophin family, including nerve growth factor (NGF), brain-derived neurotrophic factors (BDNF), and neurotrophin 3 (NT-3), are capable of supporting survival of injured CNS neurons both in vitro and in vivo. They also stimulate neurite outgrowth, needed for reorganization of the injured CNS, and the expression of key enzymes for neurotransmitter synthesis that may need to be upregulated to compensate for reduced innervation. The effects of the neurotrophins are mediated through specific high affinity trk receptors (trk A, B, C) as well as a common low affinity receptor designated p75NGFR. Another class of neurotrophic polypeptides also provides candidate recovery-promoting molecules, the heparin-binding growth factors' acidic and basic fibroblast gro...Continue Reading

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Citations

Mar 15, 2012·Cellular and Molecular Life Sciences : CMLS·Mauro W Zappaterra, Maria K Lehtinen
Dec 22, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin M MortazaviNicholas Theodore
Mar 4, 2009·Veterinary Research Communications·Hiroaki KamishinaRoger M Clemmons
Dec 17, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jian-Guo HuHe-Zuo Lü
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Sep 12, 2000·Neurosurgery·L F Marshall

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