Neurotrophic regulation of fibroblast dedifferentiation during limb skeletal regeneration in the axolotl (Ambystoma mexicanum)

Developmental Biology
Akira SatohDavid M Gardiner

Abstract

The ability of animals to repair tissue damage is widespread and impressive. Among tissues, the repair and remodeling of bone occurs during growth and in response to injury; however, loss of bone above a threshold amount is not regenerated, resulting in a "critical-size defect" (CSD). The development of therapies to replace or regenerate a CSD is a major focus of research in regenerative medicine and tissue engineering. Adult urodeles (salamanders) are unique in their ability to regenerate complex tissues perfectly, yet like mammals do not regenerate a CSD. We report on an experimental model for the regeneration of a CSD in the axolotl (the Excisional Regeneration Model) that allows for the identification of signals to induce fibroblast dedifferentiation and skeletal regeneration. This regenerative response is mediated in part by BMP signaling, as is the case in mammals; however, a complete regenerative response requires the induction of a population of undifferentiated, regeneration-competent cells. These cells can be induced by signaling from limb amputation to generate blastema cells that can be grafted to the wound, as well as by signaling from a nerve and a wound epithelium to induce blastema cells from fibroblasts within ...Continue Reading

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Citations

Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Soshiro KashioMasayuki Miura
Oct 13, 2012·Seminars in Cell & Developmental Biology·Prayag MurawalaJoshua D Currie
Apr 20, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Lina SunDavid M Gardiner
Dec 17, 2010·Development, Growth & Differentiation·Akira SatohDavid M Gardiner
Dec 1, 2010·Osteoarthritis and Cartilage·R S CosdenJ N MacLeod
Jul 18, 2012·Osteoarthritis and Cartilage·R S Cosden-DeckerJ N MacLeod
Jun 19, 2013·Developmental Biology·Aki MakanaeAkira Satoh
Nov 28, 2012·PloS One·Jangwoo Lee, David M Gardiner
Jun 25, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alessandra Dall'Agnese, Pier Lorenzo Puri
Mar 5, 2011·Gerontology·Catherine McCusker, David M Gardiner
Jan 5, 2018·Regeneration·David L Stocum
Aug 31, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Aki Makanae, Akira Satoh
May 28, 2014·Development, Growth & Differentiation·Shiro EgawaKoji Tamura
Jul 28, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Miyuki MoriyasuAkira Satoh
Jun 1, 2014·Regeneration·Aki MakanaeAkira Satoh
Nov 26, 2015·Tissue Engineering. Part B, Reviews·Lina M QuijanoTabassum Ahsan
Jan 5, 2011·Organogenesis·Fengyu SongDavid L Stocum

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