PMID: 8464867Apr 1, 1993Paper

Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture

Proceedings of the National Academy of Sciences of the United States of America
F Hory-LeeE Frank

Abstract

Target-dependent cell death of different sub-populations of sensory neurons may be regulated by different trophic factors. To investigate this possibility, we have taken advantage of the fact that the fractions of muscle sensory and cutaneous sensory neurons in chicken dorsal root ganglia (DRG) are probably different at different segmental levels, and we have compared the responses of chicken DRG from levels that do and do not innervate limb tissue to various growth factors in vitro. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) both supported neurite outgrowth from DRG explanted from all segmental levels. In contrast, neurotrophin 3 (NT-3) supported robust neurite growth only from DRG explanted from the cervical or lumbar levels, which innervate limb muscles. Similarly, NGF and BDNF both promoted survival of dissociated neurons from limb and nonlimb segmental levels, whereas NT-3 promoted survival of more neurons from limb compared to nonlimb levels. This suggests that muscle sensory neurons, which are probably more prevalent at the cervical and lumbar levels, may be specifically affected by NT-3. To evaluate this possibility directly, we compared the survival of retrogradely labeled muscle and cutaneo...Continue Reading

References

Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos

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Citations

Sep 1, 1996·Annals of Neurology·E C Yuen, W C Mobley
Feb 1, 1996·Molecular Neurobiology·A Chalazonitis
Sep 1, 1996·Brain & Development·E C YuenW C Mobley
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May 15, 2001·The Journal of Physiology·L M MendellV L Arvanian

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