Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor.

Developmental Biology
Ami V Patel, Robin F Krimm

Abstract

The number of neurons in the geniculate ganglion that are available to innervate taste buds is regulated by neurotrophin-4 (NT-4) and brain-derived neurotrophic factor (BDNF). Our goal for the current study was to examine the timing and mechanism of NT-4-mediated regulation of geniculate neuron number during development. We discovered that NT-4 mutant mice lose 33% of their geniculate neuronal cells between E10.5 and E11.5. By E11.5, geniculate axons have just reached the tongue and do not yet innervate their gustatory targets; thus, NT-4 does not function as a target-derived growth factor. At E11.5, no difference was observed in proliferating cells or the rate at which cells exit the cell cycle between NT-4 mutant and wild type ganglia. Instead, there was an increase in TUNEL-labeling, indicating an increase in cell death in Ntf4(-/-) mice compared with wild types. However, activated caspase-3, which is up-regulated in the absence of BDNF, was not increased. This finding indicates that cell death initiated by NT-4-removal occurs through a different cell death pathway than BDNF-removal. We observed no additional postnatal loss of taste buds or neurons in Ntf4(-/-) mice. Thus, during early embryonic development, NT-4 produced in...Continue Reading

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Citations

Aug 13, 2013·Neuroscience·Sara L CorsonRobert M Bradley
Jan 1, 2014·Developmental Biology·Tao Huang, Robin F Krimm
Dec 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Christopher R DonnellyBrian A Pierchala
Jan 30, 2019·Neural Development·Jennifer Rios-Pilier, Robin F Krimm
Nov 10, 2014·Metabolic Brain Disease·Lingbin MengRui Ji
Sep 1, 2017·The Journal of Comparative Neurology·Lisa Ohman-GaultRobin Krimm

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