Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle

American Journal of Physiology. Lung Cellular and Molecular Physiology
Y S PrakashChristina M Pabelick

Abstract

Neurotrophins [e.g., brain-derived neurotrophic factor (BDNF), neurotrophin 4 (NT4)], known to affect neuronal structure and function, are expressed in nonneuronal tissues including the airway. However, their function is unclear. We examined the effect of acute vs. prolonged neurotrophin exposure on regulation of airway smooth muscle (ASM) intracellular Ca(2+) concentration ([Ca(2+)](i)): sarcoplasmic reticulum (SR) Ca(2+) release and Ca(2+) influx (specifically store-operated Ca(2+) entry, SOCE). Human ASM cells were incubated for 30 min in medium (control) or 1 or 10 nM BDNF, NT3, or NT4 (acute exposure) or overnight in 1 nM BDNF, NT3, or NT4 (prolonged exposure) and imaged after loading with the Ca(2+) indicator fura-2 AM. [Ca(2+)](i) responses to ACh, histamine, bradykinin, and caffeine and SOCE following SR Ca(2+) depletion were compared across cell groups. Force measurements were performed in human bronchial strips exposed to neurotrophins. Basal [Ca(2+)](i), peak responses to all agonists, SOCE, and force responses to ACh and histamine were all significantly enhanced by both acute and prolonged BDNF exposure (smaller effect of NT4) but decreased by NT3. Inhibition of the BDNF/NT4 receptor trkB by K252a prevented enhancem...Continue Reading

References

Dec 1, 1992·Journal of Neurochemistry·B Knüsel, F Hefti
Apr 1, 1991·The Journal of Physiology·R K Murray, M I Kotlikoff
Apr 1, 1990·The American Journal of Physiology·R F Coburn, C B Baron
Dec 1, 1990·The American Journal of Physiology·J F Worley, M I Kotlikoff
Nov 1, 1994·Journal of Neurobiology·M V Chao
Apr 1, 1995·Journal of Neurochemistry·C Lomen-Hoerth, E M Shooter
Jan 1, 1994·Annals of Neurology·N Y Ip, G D Yancopoulos
Nov 1, 1995·British Journal of Pharmacology·Y ItoT Tomita
Apr 1, 1996·Journal of Neurochemistry·L LärkforsR F Alderson
Mar 1, 1997·The American Journal of Physiology·Y S PrakashG C Sieck
Apr 1, 1997·The American Journal of Physiology·M S KannanG C Sieck
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M CanossaH Thoenen
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·A de VriesF P Nijkamp
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·A BraunH Renz
Dec 2, 1999·Experimental Cell Research·W J Friedman, L A Greene
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J W Putney
Mar 14, 2000·Current Biology : CB·A M Davies
Jun 14, 2000·Current Opinion in Neurobiology·D R Kaplan, F D Miller
Oct 12, 2000·Journal of Vascular Research·A RicciS Mariotta
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Aug 18, 2001·Journal of Applied Physiology·L J JanssenT Tazzeo
Aug 18, 2001·Journal of Applied Physiology·K M Sanders
Sep 1, 2001·Cellular and Molecular Life Sciences : CMLS·H Sariola
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·A RicciG Barbolini
Mar 2, 2002·Science·Yury KovalchukArthur Konnerth
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Satoru ItoHideharu Hayashi
Apr 5, 2003·Annual Review of Biochemistry·Eric J Huang, Louis F Reichardt
Jun 7, 2003·American Journal of Respiratory Cell and Molecular Biology·Alberto RicciElena Bronzetti
Jun 10, 2003·Annals of the New York Academy of Sciences·Marek LommatzschHarald Renz
Oct 18, 2003·Cytokine & Growth Factor Reviews·Gary W Hoyle
Oct 18, 2003·Cytokine & Growth Factor Reviews·Wolfgang Andreas Nockher, Harald Renz
Nov 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Binnaz AyGary C Sieck
Jan 1, 2004·Progress in Brain Research·Christina NassensteinArmin Braun
Jan 6, 2004·Cellular and Molecular Life Sciences : CMLS·K K Teng, B L Hempstead
Feb 26, 2004·Muscle & Nerve·Carlos B MantillaGary C Sieck
Jul 28, 2004·Anesthesiology·Christina M PabelickGary C Sieck
Oct 7, 2004·Current Opinion in Neurobiology·Yury KovalchukArthur Konnerth
Jan 19, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko Chiba, Miwa Misawa
Mar 25, 2005·Physiological Reviews·Anant B Parekh, James W Putney
Apr 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qin YaoRichard J Martin
Apr 26, 2005·Respiratory Physiology & Neurobiology·Ofir BacharLars-Olaf Cardell

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Citations

Apr 19, 2011·Cardiovascular Research·Lucas W MeuchelY S Prakash
Jun 8, 2012·American Journal of Physiology. Cell Physiology·Philippe DelmotteGary C Sieck
Aug 26, 2011·American Journal of Physiology. Cell Physiology·Susan G DorseyChristopher W Ward
Aug 2, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Venkatachalem SathishChristina M Pabelick
Jun 3, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ramadan B SopiSyed I A Zaidi
Apr 26, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lucas W MeuchelY S Prakash
Feb 14, 2009·American Journal of Respiratory Cell and Molecular Biology·Y S PrakashChristina M Pabelick
Dec 22, 2012·American Journal of Respiratory Cell and Molecular Biology·Venkatachalem SathishY S Prakash
Feb 25, 2014·Pharmacology & Therapeutics·Y S Prakash, Richard J Martin
Jun 10, 2011·Journal of Cellular and Molecular Medicine·Bharathi AravamudanY S Prakash
Apr 24, 2015·Science Translational Medicine·Polina L YarovaDaniela Riccardi
Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Al-QudahJ R Grider
Jun 27, 2015·Biochimica Et Biophysica Acta·Michael A ThompsonY S Prakash
Jan 28, 2014·Journal of Molecular and Cellular Cardiology·Martin HelanY S Prakash
Aug 1, 2013·Biochimica Et Biophysica Acta·Pawan K VohraY S Prakash
Jul 31, 2016·Journal of Cellular Physiology·Bharathi AravamudanY S Prakash
Oct 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rodney D BrittY S Prakash
Feb 18, 2018·Current Allergy and Asthma Reports·Juliana Barrios, Xingbin Ai
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stéphane P DufourRuddy Richard
Jan 30, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jeremy BardenRussell S Richardson
Jul 19, 2008·Journal of Applied Physiology·Jan T GroothuisMaria T E Hopman
Jan 10, 2009·Journal of Applied Physiology·Roy J Shephard
Jun 9, 2010·Expert Review of Respiratory Medicine·Ys PrakashRichard J Martin
Jun 19, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bharathi AravamudanY S Prakash
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Al-QudahJ R Grider
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michelle R FreemanY S Prakash
Nov 4, 2016·Journal of Cellular Physiology·Bharathi AravamudanVenkatachalem Sathish
Jan 10, 2009·Journal of Applied Physiology·Timothy David Noakes, Frank E Marino
Jun 30, 2007·Journal of Applied Physiology·Jose A L CalbetBengt Saltin
Aug 14, 2020·Physiology·Pien A GoldsteenReinoud Gosens
Mar 13, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bharathi AravamudanY S Prakash
Oct 22, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
Aug 30, 2014·Journal of Applied Physiology·Carlos B MantillaGary C Sieck
Mar 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael K SticklandJerome A Dempsey
Jul 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dan F SmelterY S Prakash
Jun 26, 2021·Journal of Cellular Physiology·Sangeeta BhallamudiY S Prakash

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