Abstract
The recurrent laryngeal nerve (RLN) commonly regenerates after injury; however, functional motion is rarely recovered. Animal experiments have documented aberrant reinnervation after nerve transection, with motor axons reaching inappropriate muscles. More recently, experimental results suggest that lack of vocal fold motion after RLN injury is due to preferential reinnervation of adductor muscles, with inadequate reinnervation of the posterior cricoarytenoid muscle (PCA), the only abductor muscle of the larynx. Information on factors that could influence the receptiveness of these muscles to reinnervation could be useful in developing new therapeutic strategies. It is hypothesized that the thyroarytenoid muscle (TA) and the PCA differ in expression of neurotrophins in response to denervation. Laboratory experiment. Rats were sacrificed at 3 days, 6 weeks, or 4 months after unilateral RLN injury measure expression of brain-derived nerve growth factor (BDNF), nerve growth factor (NGF), and neurotrophin 4 (NT-4) in the TA and PCA muscles, using immunohistochemistry. We also assessed nerve regeneration. NGF was significantly diminished in the denervated TA muscle at 3 days after injury and increased at 6 weeks. BDNF expression was ...Continue Reading
References
Jun 1, 1992·The Laryngoscope·M L ShindoV Sahgal
Apr 1, 1991·The Laryngoscope·R L Crumley
Oct 1, 1991·The Annals of Otology, Rhinology, and Laryngology·P W FlintM D Coltrera
Jul 1, 1989·The Annals of Otology, Rhinology, and Laryngology·J P MarieJ Senant
Feb 1, 1989·The Annals of Otology, Rhinology, and Laryngology·R L Crumley
Feb 1, 1968·The Laryngoscope·J H Gordon, B F McCabe
Jul 1, 1982·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R L Crumley, B F McCabe
Jan 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·H Thoenen
Oct 1, 1993·The Journal of Cell Biology·H FunakoshiH Persson
Sep 1, 1995·Journal of Neuroscience Research·O GriesbeckH Thoenen
Dec 1, 1996·The Laryngoscope·H ZhengW Wen
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
May 5, 1999·Journal of Anatomy·G Terenghi
Dec 2, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A D HillelS Schaefer
Jun 30, 2001·Brain Research·K SakumaT Totsuka
Apr 23, 2003·Journal of Voice : Official Journal of the Voice Foundation·Carla A BrandonJames J Sciote
Feb 20, 2007·The Annals of Otology, Rhinology, and Laryngology·Gayle E Woodson
Feb 27, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Walter T LeeRamon M Esclamado
Apr 12, 2007·Journal of Neuroendocrinology·J TetzlaffK J Jones
Aug 30, 2008·The Laryngoscope·Gayle E WoodsonRobert Helfert
Citations
Sep 12, 2012·The Laryngoscope·Stacey L HalumKelly Hiatt
May 29, 2013·The Laryngoscope·Michael J PitmanSansar Sharma
Sep 3, 2014·Journal of Anatomy·G Berdugo-VegaA Pascual-Font
Aug 7, 2013·The Laryngoscope·Opeyemi AlliMichael J Pitman
Apr 10, 2016·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Sep 16, 2014·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Jul 17, 2016·Neuroscience·Ignacio Hernandez-MoratoMichael J Pitman
Aug 26, 2016·Scientific Reports·Baoxin WangPin Dong
Sep 13, 2017·The Laryngoscope·Gerhard Foerster, Andreas H Mueller
Feb 28, 2019·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Dec 18, 2015·Molecular Medicine Reports·Baoxin WangPin Dong
Apr 8, 2020·Cellular and Molecular Life Sciences : CMLS·Vlasta Lungova, Susan L Thibeault
Jun 27, 2018·Genes·Koji ArakiAkihiro Shiotani