Neurotrophin expression of laryngeal muscles in response to recurrent laryngeal nerve transection

The Laryngoscope
Xavier Vega-CordovaGayle E Woodson

Abstract

The recurrent laryngeal nerve (RLN) commonly regenerates after injury; however, functional motion is rarely recovered. Animal experiments have documented aberrant reinnervation after nerve transection, with motor axons reaching inappropriate muscles. More recently, experimental results suggest that lack of vocal fold motion after RLN injury is due to preferential reinnervation of adductor muscles, with inadequate reinnervation of the posterior cricoarytenoid muscle (PCA), the only abductor muscle of the larynx. Information on factors that could influence the receptiveness of these muscles to reinnervation could be useful in developing new therapeutic strategies. It is hypothesized that the thyroarytenoid muscle (TA) and the PCA differ in expression of neurotrophins in response to denervation. Laboratory experiment. Rats were sacrificed at 3 days, 6 weeks, or 4 months after unilateral RLN injury measure expression of brain-derived nerve growth factor (BDNF), nerve growth factor (NGF), and neurotrophin 4 (NT-4) in the TA and PCA muscles, using immunohistochemistry. We also assessed nerve regeneration. NGF was significantly diminished in the denervated TA muscle at 3 days after injury and increased at 6 weeks. BDNF expression was ...Continue Reading

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Citations

Sep 3, 2014·Journal of Anatomy·G Berdugo-VegaA Pascual-Font
Aug 7, 2013·The Laryngoscope·Opeyemi AlliMichael J Pitman
Apr 10, 2016·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Sep 16, 2014·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Jul 17, 2016·Neuroscience·Ignacio Hernandez-MoratoMichael J Pitman
Feb 28, 2019·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Apr 8, 2020·Cellular and Molecular Life Sciences : CMLS·Vlasta Lungova, Susan L Thibeault
Jun 27, 2018·Genes·Koji ArakiAkihiro Shiotani

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