Neurotrophin-like immunoreactivity in the human trigeminal ganglion

Neuroreport
M QuartuM Del Fiacco

Abstract

The localization of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3) was demonstrated immunohistochemically in discrete neuronal subsets of the human trigeminal ganglion at ages ranging from 23 weeks of gestation to adulthood. Neurotrophin-containing subpopulations partially overlapped with each other and with those immunoreactive for the relevant trk receptor. Glial elements could also be immunostained, labelled satellite cells being particularly abundant in NT-3 stained sections. These results suggest that the neurotrophins are of functional significance for the human trigeminal primary sensory neurones throughout life. Their localization in the ganglion cellular components supports their function as target-derived trophic factors and as molecules effective in autocrine/paracrine interactions.

References

Jan 16, 1995·The Journal of Comparative Neurology·D E Wright, W D Snider
Mar 1, 1994·Current Biology : CB·A M Davies
May 6, 1994·Science·M Barinaga
Oct 1, 1995·Current Opinion in Neurobiology·S B McMahon, J V Priestley
Nov 1, 1995·Trends in Neurosciences·H M Schätzl
Dec 1, 1995·Current Opinion in Cell Biology·M C Birling, J Price
Jan 1, 1996·Seikagaku. The Journal of Japanese Biochemical Society·Y FurukawaK Hayashi
Feb 1, 1996·Neuron·W D Snider, D E Wright
Jan 1, 1996·Annual Review of Neuroscience·G R Lewin, Y A Barde
Jul 1, 1996·Neurochemical Research·A M Davies

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Citations

Dec 1, 1996·Trends in Neurosciences·B R PayneJ Bullier
Jun 5, 1999·Brain Research Bulletin·M QuartuM Del Fiacco
Feb 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marina QuartuMarina Del Fiacco
Apr 6, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Yossef S LevyDaniel Offen
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Arden K HegtvedtErick M Rath
Aug 16, 2011·Brain Research·Oscar V RamosJack Yamuy
Nov 20, 2018·Journal of Neuroscience Research·Wenguo FanHongwen He
Sep 25, 2002·Physiological Reviews·Linda R Watkins, Steven F Maier

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