Neurotrophin receptor immunostaining in the rat ventral cochlear nucleus

Brain Research
A BuretteR Romand

Abstract

By virtue of its known segregated distribution of cell types, their known neurotransmitters and neurophysiologic properties, the cochlear nucleus is an excellent model and provides the opportunity to study the relation between neurotrophins and their receptors along with the functional properties of the adult cochlear nucleus. To investigate the potential role of neurotrophins in the mature cochlear nucleus, we determined the expression of the three major neurotrophin tyrosine kinase receptors (Trk) in the adult rat ventral cochlear nucleus, as revealed by antibodies against the full-Trk proteins. A qualitative and a cartographic analysis showed a widespread distribution of the three Trk receptors throughout the nucleus. Immunostaining was mainly restricted to neurons as shown by the lack of double immunostaining with specific markers for glial cells. However, we observed variability in immunostaining for given receptors. Three classes of cells were distinguished by their specificity for Trk receptors. The first one was a cell population that stained for TrkA or TrkB. This population characterizes the majority of small and small round neurons and fusiform cells. The second group consists of TrkC-immunolabeled cells and comprise...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J FrisénM Risling
Sep 1, 1992·Trends in Neurosciences·S O Meakin, E M Shooter
Jun 1, 1974·The Journal of Comparative Neurology·J R BrawerE C Kane
Aug 1, 1969·The Journal of Comparative Neurology·K K Osen
Mar 1, 1966·The Journal of Comparative Neurology·J M Harrison, R Irving
May 10, 1984·The Journal of Comparative Neurology·E M Rouiller, D K Ryugo
Feb 1, 1982·The American Journal of Anatomy·D B Webster, D R Trune
Oct 27, 1995·Science·H Thoenen
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Jun 1, 1995·Brain Research. Molecular Brain Research·M DragunowL F Nicholson
Jun 5, 1995·The Journal of Comparative Neurology·Y MuragakiV M Lee
Mar 1, 1995·Visual Neuroscience·D W Rickman, N C Brecha
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Mar 21, 1994·Brain Research·B Cheng, M P Mattson
May 1, 1994·The European Journal of Neuroscience·J S RudgeN Y Ip
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J FrisénD Lindholm
Apr 8, 1996·The Journal of Comparative Neurology·A HafidiD H Sanes
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D CalifanoV de Franciscis

❮ Previous
Next ❯

Citations

May 30, 1998·Microscopy Research and Technique·A BuretteR Romand
Dec 31, 2003·Hearing Research·C F DaiA L Nuttall
Apr 30, 2004·The Journal of Comparative Neurology·Beatriz Benítez-TemiñoAngel M Pastor
Jul 18, 2009·Journal of Neuroscience Research·J FengD K Morest
Dec 6, 2016·International Journal of Molecular Sciences·Beatriz Benítez-TemiñoAngel M Pastor
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T YamashiroT Takano-Yamamoto
Mar 30, 2005·Journal of Neuroscience Research·Sanoj K SunejaSteven J Potashner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.