PMID: 9159175May 27, 1997Paper

Neurotrophin regulation of ionic currents and cell size depends on cell context

Proceedings of the National Academy of Sciences of the United States of America
N T SherwoodD C Lo

Abstract

Trk receptor activation by neurotrophins is often considered to have a defined set of actions on target neurons, including supporting neuronal survival, inducing morphological differentiation, and regulating a host of target genes that specify neuronal phenotype. It is not known if all such regulatory effects are obligatory, or if some may vary depending on the cell context in which the receptors are expressed. We have examined this issue by comparing neurotrophin effects on the regulation of electrical excitability and morphological differentiation in two strains of PC12 cells. We found that while neurotrophins induced neurite extension and increased calcium currents in both PC12 cell types, sodium current levels were regulated in only one of these strains. Moreover, we found little correlation between calcium current levels and the extent of morphological differentiation when compared in individual cells of a single strain. Thus, the regulatory effects of neurotrophins on cell phenotype are not fully determined by the Trk receptors that they activate; rather, they can vary with differences in cell context that arise not only between different cell lineages, but also between individual cells of clonal relation.

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Citations

Feb 11, 2004·Progress in Biophysics and Molecular Biology·Caroline BordayMuriel Thoby-Brisson
Feb 13, 1999·Progress in Neurobiology·M J Millan
Apr 2, 1999·The European Journal of Neuroscience·P BaldelliE Carbone
Nov 9, 2000·The European Journal of Neuroscience·P BaldelliE Carbone
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KrüttgenE M Shooter
Jan 1, 1997·Molecular and Cellular Neurosciences·S S LesserD C Lo
Jan 29, 2000·Nature Neuroscience·T A Nick, A B Ribera
Oct 3, 2001·Nature Biotechnology·M J Mahoney, W M Saltzman
Apr 23, 2008·Current Protocols in Neuroscience·D C Lo

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