Neurotrophin therapy improves recovery of the neuromuscular continence mechanism following simulated birth injury in rats.

Neurourology and Urodynamics
Bradley GillMargot S Damaser

Abstract

Stress urinary incontinence (SUI) affects women both acutely and chronically after vaginal delivery. Current SUI treatments assume the neuromuscular continence mechanism, comprised of the pudendal nerve (PN) and external urethral sphincter (EUS), is either intact or irreparable. This study investigated the ability of neurotrophin therapy to facilitate recovery of the neuromuscular continence mechanism. Virgin, Sprague Dawley rats received simulated childbirth injury or sham injury and treatment with continuous infusion of brain-derived neurotrophic factor (BDNF) or saline placebo to the site of PN injury. Continence was assessed by leak point pressure (LPP) and EUS electromyography (EMG) 14 and 21 days after injury. Structural recovery was assessed histologically. Molecular assessment of the muscular and neuroregenerative response was determined via measurement of EUS BDNF and PN β(II) -tubulin expression respectively, 4, 8, and 12 days after injury. Following injury, LPP was significantly reduced with saline compared to either BDNF treatment or sham injury. Similarly, compared to sham injury, resting EUS EMG amplitude and firing rate, as well as amplitude during LPP were significantly reduced with saline but not BDNF treatment...Continue Reading

References

Sep 1, 1990·British Journal of Obstetrics and Gynaecology·R E AllenD W Warrell
Dec 1, 1990·The British Journal of Surgery·S J SnooksM M Henry
Jan 1, 1989·British Journal of Obstetrics and Gynaecology·A R SmithD W Warrell
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D G WellsJ R Fallon
May 5, 1999·Journal of Anatomy·G Terenghi
May 8, 2000·Neurourology and Urodynamics·K SakamotoM S Damaser
Dec 21, 2000·The European Journal of Neuroscience·J Y ZhangX F Zhou
Mar 7, 2003·The New England Journal of Medicine·Guri RortveitUNKNOWN Norwegian EPINCONT Study
Nov 19, 2003·The European Journal of Neuroscience·Magda SimonGiorgio Terenghi
May 29, 2004·Clinical Obstetrics and Gynecology·W Thomas Gregory, Ingrid Nygaard
Oct 14, 2005·Journal of the Peripheral Nervous System : JPNS·Takao OmuraAkira Nagano
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kambiz Mousavi, Bernard J Jasmin
Jan 22, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·L K CarrM B Chancellor
Feb 15, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·P M LattheK Khan
Nov 1, 2008·Neurourology and Urodynamics·Hai-Hong JiangMargot Damaser
Dec 6, 2008·Experimental Neurology·Hai-Hong JiangMargot S Damaser
Dec 19, 2008·American Journal of Physiology. Renal Physiology·Hui Q PanMargot S Damaser
May 27, 2011·American Journal of Physiology. Renal Physiology·Hardeep S PhullMargot S Damaser

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Citations

Sep 17, 2014·Nature Reviews. Urology·Qi-Xiang SongMargot S Damaser
Apr 19, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhiro Sumino, Hiromitsu Mimata
Jul 26, 2015·Autonomic Neuroscience : Basic & Clinical·Christopher J Chermansky, Pamela A Moalli
Apr 16, 2019·Current Opinion in Urology·Brian M BalogMargot S Damaser
Jul 15, 2021·Scientific Reports·Kristine JanssenMargot S Damaser

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