PMID: 9786341Oct 24, 1998

Neurotrophin trafficking by anterograde transport

Trends in Neurosciences
C A Altar, P S DiStefano

Abstract

The ever-unfolding biology of NGF is consistent with a target-derived retrograde mode of action in peripheral and central neurons. However, another member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), is present within nerve terminals in certain regions of the brain and PNS that do not contain the corresponding mRNA. Recent studies have shown that the endogenous neurotrophins, BDNF and neurotrophin-3 (NT-3), are transported anterogradely by central and peripheral neurons. The supply of BDNF by afferents is consistent with their presynaptic synthesis, vesicular storage, release and postsynaptic actions. Anterograde axonal transport provides an 'afferent supply' of BDNF and NT-3 to neurons and target tissues, where they function as trophic factors and as neurotransmitters.

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Related Concepts

Axonal Transport
Neurons
Peripheral Nervous System
Brain
Recombinant Brain-Derived Growth Factors
Anterograde Axon Cargo Transport
NTF3
Brain-Derived Neurotrophic Factor Measurement
Synaptic Transmission
Neurotrophic factor

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