Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity.

Journal of Alzheimer's Disease : JAD
Yan ZengCui-Wei Xie

Abstract

Amyloid-β (Aβ) peptide-induced impairment of hippocampal synaptic plasticity is considered an underlying mechanism for memory loss in the early stages of Alzheimer's disease and its animal models. We previously reported inhibition of long-term potentiation (LTP) and miniature excitatory postsynaptic currents by oligomeric Aβ(1-42) at hippocampal synapses. While multiple cellular mechanisms could be involved in Aβ-induced synaptic dysfunction, blockade of activity-dependent autophosphorylation of Ca2+ and calmodulin-dependent protein kinase II (CaMKII) appeared to be a major component of Aβ action in our studies. The present study further tested this hypothesis and examined the therapeutic potential of trkB receptor-acting neurotrophins in rescuing Aβ-induced synaptic and signaling impairments. As expected, treatment of rat hippocampal slices with Aβ(1-42) significantly reduced LTP in the Schaffer collateral-CA1 pathway and dentate medial perforant path. LTP-associated CaMKII activation and AMPA receptor phosphorylation were blocked by Aβ(1-42) at the same concentration that inhibited LTP. Aβ-induced LTP impairment, however, was prevented when slices were co-treated with neurotrophin 4 (NT4). Western blotting and immunohistochem...Continue Reading

Citations

Apr 27, 2012·Rejuvenation Research·Marta BaliettiGiorgio Aicardi
Feb 1, 2011·Molecular Brain·Elaine E IrvineK Peter Giese
Aug 4, 2012·PloS One·Lívia FülöpTamás A Martinek
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan ZengCui-Wei Xie
Mar 23, 2011·International Journal of Alzheimer's Disease·Sara AnsaloniAleister J Saunders
Feb 13, 2016·Frontiers in Aging Neuroscience·Roberta ZanardiniRoberta Ghidoni
Mar 13, 2013·International Journal of Molecular Sciences·Dong-Mei WangLian-Feng Zhang
Mar 18, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Julien Gibon, Philip A Barker
Dec 19, 2017·Frontiers in Neuroscience·Luisa BenussiRoberta Ghidoni
Aug 18, 2017·Journal of Cellular and Molecular Medicine·Paula Alexandra PostuLucian Hritcu
Feb 23, 2012·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
Aug 24, 2012·Molecular Neurobiology·Robert NisticòGraham Collingridge
Jan 13, 2017·Molecular Medicine·Moustapha CisséFrédéric Checler
Apr 12, 2016·Journal of Alzheimer's Disease : JAD·Qing YeZhijun Zhang
Sep 17, 2020·Cell and Tissue Research·Aaron Johnstone, William Mobley
May 11, 2016·Neurochemical Research·Ruifeng DuanZhiqing Zhang
Nov 25, 2016·Frontiers in Molecular Neuroscience·Wanda M Snow, Benedict C Albensi
May 7, 2019·Molecular Medicine Reports·Yichen YinGuoqing Guo
Feb 26, 2016·Molecular Neurobiology·Peixing WanYehong Zhuo
Oct 31, 2014·Molecular Neurobiology·Jing-Hui SongLan Tan
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Olivia BelbinDonald J Lehmann
Mar 4, 2020·CNS & Neurological Disorders Drug Targets·Anamaria Jurcau, Aurel Simion
Nov 26, 2015·Molecular Brain·Anshua Ghosh, Karl Peter Giese
Apr 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jie XiangKeqiang Ye
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Chuang WangHan-Ting Zhang
Mar 28, 2018·Journal of Internal Medicine·R Loera-ValenciaP Nilsson
Feb 16, 2019·The Journal of Physiological Sciences : JPS·Ge JinLibo Zou
Oct 8, 2020·Journal of Neuroinflammation·Shaghayegh SadeghmousaviNima Rezaei
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka
Jun 19, 2017·Neuroscience and Biobehavioral Reviews·Cristina PinarBrian R Christie
Jun 3, 2021·Journal of Functional Morphology and Kinesiology·Elisa InnocenziPaola Grimaldi
Sep 18, 2013·Learning & Memory·Karl Peter Giese, Keiko Mizuno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.