Nov 22, 2018

Neurovascular coupling preserved in a chronic mouse model of Alzheimers disease: Methodology is critical.

BioRxiv : the Preprint Server for Biology
Paul S SharpJason Berwick


Neurovascular coupling is the process by which neural activity causes localised changes in cerebral blood flow. Impaired neurovascular coupling has been suggested as an early pathogenic factor in Alzheimers disease (AD), and if so, could serve as an early biomarker of cerebral pathology. We have established an anaesthetic regime in which evoked hemodynamic responses are comparable to those in awake mice. This protocol was adapted to allow repeated measurements of neurovascular function over three months in the hAPP-J20 mouse model of AD (J20-AD) and wild-type (WT) controls. Animals were 9-12 months old at the start of the experiment, which is when deficits due to the disease condition would be expected. Mice were chronically prepared with a cranial window through which optical imaging spectroscopy (OIS) was used to generate functional maps of the cerebral blood volume and saturation changes evoked by whisker stimulation and vascular reactivity challenges. Unexpectedly, the hemodynamic responses were largely preserved in the J20-AD group. This result failed to confirm previous investigations using the J20-AD model. However, a final acute electrophysiology and OIS experiment was performed to measure both neural and hemodynamic re...Continue Reading

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Mentioned in this Paper

Biological Markers
Cerebral Blood Flow Imaging
Pathogenic Organism
Blood Vessel
Alzheimer's Disease
Optical Imaging
Blood Flow
Neurovascular Bundle
Stimulation Procedure

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