PMID: 9426079Jan 13, 1998Paper

Neutral endopeptidase inhibition with inhaled phosphoramidon: no effect on bronchial responsiveness to adenosine 5'-monophosphate (AMP) in asthma

The European Respiratory Journal
Riccardo PolosaN Crimi

Abstract

Part of the contractile response of adenosine in the asthmatic airways may be due to the activation of peptidergic pathways with subsequent local release of spasmogenic neuropeptides. At present, little is known about the potential role of lung peptidases in modulating adenosine-induced airway dysfunction in humans in vivo. We have, therefore, investigated the change in bronchial reactivity to adenosine 5'-monophosphate (AMP), after treatment with inhaled phosphoramidon, a potent neutral endopeptidase (NEP) inhibitor, in a double-blind, placebo-controlled, randomized study of 12 asthmatic subjects. Subjects attended on six separate occasions, during which concentration response studies with inhaled AMP and methacholine were carried out, initially in the absence of treatment and then after nebulized phosphoramidon sodium salt (10[-5] M) or matched placebo 5 min prior to a bronchoprovocation test with AMP or methacholine. Agonist responsiveness was expressed as the provocative concentration of AMP or methacholine producing a 20% fall in FEV1 from baseline (PC[20,AMP] or PC[20,meth], respectively). When compared to placebo, phosphoramidon failed to potentiate the airway response to AMP. The geometric mean (range) PC20 AMP value of...Continue Reading

Citations

Jun 28, 2011·American Journal of Respiratory Cell and Molecular Biology·Luigino CalzettaMaria G Matera
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L PangA J Knox
Mar 4, 2008·British Journal of Pharmacology·R A BrownC P Page
Feb 2, 2006·Fundamental & Clinical Pharmacology·Cristina RussoRiccardo Polosa
Sep 7, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena Mizerska-Dudka, Martyna Kandefer-Szerszeń
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Rebecca NormansellParameswaran Nair

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