PMID: 8602728Mar 22, 1996Paper

Neutral endopeptidase modulates septic shock

Annals of the New York Academy of Sciences
B LuC Gerard

Abstract

Neutral endopeptidase (NEP; EC 3.4.24.11) is a type-2 cell-surface metalloproteinase known by a variety of eponyms, including enkephalinase, common acute lymphoblastic leukemia antigen (CALLA), and CD10. Identified substrates are largely neural or humoral oligopeptide agonists, and the enzyme functions to terminate signaling by degrading the ligand, analogous to the acetylcholine/acetylcholinesterase system. Targeted disruption of the NEP locus in mice results in enhanced lethality to endotoxin shock with a pronounced gene-dosage effect. The site(s) of action appears downstream from release of TNF and IL-1, as NEP-deficient animals demonstrate increased sensitivity to these mediators as well. This unexpected finding indicates an important protective role for NEP in septic shock.

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Citations

Jan 7, 2005·Biology of Reproduction·Jean-Luc GattiJean-Louis Dacheux
May 4, 2004·Molecular and Cellular Biology·Mélanie CarpentierJean Charron
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·A J CohenY E Miller
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·A J CohenY E Miller
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Marilee J WickEdward C Dempsey
Jul 26, 2013·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Takaomi C Saido
Feb 21, 2004·International Immunopharmacology·Gaku MitsuiMasatoshi Kato
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Carlos BecharaChangyi Chen
Jul 25, 2019·Glia·Ilaria CervelliniDavid L H Bennett
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCgtp Collaborators
May 20, 2020·Journal of the American Heart Association·Suriya PrausmüllerMartin Hülsmann
Jul 10, 2002·The Journal of Biological Chemistry·M Hasan MohajeriRoger M Nitsch
Apr 14, 2010·Inhalation Toxicology·Simon S WongJefferey L Burgess

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