Neutral particle mass spectrometry with nanomechanical systems

Nature Communications
Eric SageS Hentz

Abstract

Current approaches to mass spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. Here, using a setup comprising both conventional time-of-flight MS (TOF-MS) and nano-electromechanical systems-based MS (NEMS-MS) in situ, we show directly that NEMS-MS analysis is insensitive to charge state: the spectrum consists of a single peak whatever the species' charge state, making it significantly clearer than existing MS analysis. In subsequent tests, all the charged particles are electrostatically removed from the beam, and unlike TOF-MS, NEMS-MS can still measure masses. This demonstrates the possibility to measure mass spectra for neutral particles. Thus, it is possible to envisage MS-based studies of analytes that are incompatible with current ionization techniques and the way is now open for the development of cutting-edge system architectures with unique analytical capability.

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Citations

Feb 14, 2016·Mass Spectrometry Reviews·David Z Keifer, Martin F Jarrold
Mar 2, 2016·Nature Nanotechnology·Marc SansaSébastien Hentz
Mar 30, 2016·Journal of the American Society for Mass Spectrometry·David Z KeiferMartin F Jarrold
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Apr 27, 2017·The Analyst·David Z KeiferMartin F Jarrold
Jan 6, 2018·Mass Spectrometry·Toshiki Sugai
Aug 28, 2019·Nanoscale·Tuphan DevkotaGregory V Hartland
Sep 11, 2019·Nature Communications·Stefano StassiCarlo Ricciardi
Jun 16, 2018·Science·Swapan K RoyWayne K Hiebert
Dec 16, 2017·Lab on a Chip·Mehmet KelleciM Selim Hanay
Jul 31, 2020·Nature Communications·Marc SansaSébastien Hentz
Dec 2, 2020·Physical Review Letters·Huanying SunMeiyong Liao
Jun 9, 2021·Nature Methods·Javier Antonio AlfaroChirlmin Joo
Jul 28, 2016·Journal of the American Society for Mass Spectrometry·Erica ForsbergGary Siuzdak
Jul 11, 2018·Journal of the American Society for Mass Spectrometry·Joanna A Hogan, Martin F Jarrold
Jul 9, 2021·Analytical and Bioanalytical Chemistry·Kavya ClementChristophe Masselon
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Aug 21, 2021·Chemical Reviews·Sem TamaraAlbert J R Heck
Aug 28, 2020·ACS Photonics·Miao-Hsuan ChienSilvan Schmid

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Methods Mentioned

BETA
quartz crystal microbalance

Software Mentioned

NEMS

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