Neutralization of heparin activity

Handbook of Experimental Pharmacology
Menaka Pai, Mark A Crowther

Abstract

Heparin is the mainstay in the treatment and prevention of thrombosis in such diverse clinical settings as venous thromboembolism, acute coronary syndrome, cardiopulmonary bypass, and hemodialysis. However, the major complication of heparin - like that of all anticoagulants - is bleeding. Heparin may need to be reversed in the following settings: clinically significant bleeding; prior to an invasive procedure; at the conclusion of a procedure involving extracorporeal circulation (e.g., cardiopulmonary bypass, dialysis). This chapter discusses protamine sulfate, as well as several other agents that are able to neutralize heparin, including their pharmacological properties, indications, dosing, and efficacy.

Citations

Jul 2, 2014·Marine Drugs·Barbara Lorkowska-ZawickaRyszard Korbut
Mar 19, 2016·Journal of Thrombosis and Haemostasis : JTH·K ChandarajotiR Pawlinski
Jun 28, 2017·Organic & Biomolecular Chemistry·Ryan J WeissYitzhak Tor
Aug 16, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ileana MusterWalter Knirsch
Jul 4, 2018·Journal of Thrombosis and Haemostasis : JTH·B F GlauserP A S Mourão
Apr 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Amélie I S SobczakAlan J Stewart
Oct 31, 2014·Science Translational Medicine·Rajesh A ShenoiJayachandran N Kizhakkedathu
Dec 17, 2015·Pharmacological Reviews·Barbara MulloyClive P Page
Oct 4, 2013·The Journal of Trauma and Acute Care Surgery·Jennifer L GordonMarion Dugdale
Feb 26, 2019·Frontiers in Medicine·Eduardo VilanovaPaulo A S Mourão

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