Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

The Journal of Investigative Dermatology
Nick VandeghinsteStefan Steidl

Abstract

IL-17C is a functionally distinct member of the IL-17 family that was believed to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD). An anti-IL-17C antibody, MOR106, was generated that potently and selectively binds to human and mouse IL-17C, thereby inhibiting the binding of IL-17C to its IL-17RE receptor. The antibody inhibited cutaneous inflammation in an IL-23-induced psoriatic-like skin inflammation model. In lesional skin of patients with AD, IL-17C expression levels were increased and localized to keratinocytes and infiltrating immune cells. To determine the contribution of IL-17C to AD pathogenesis, MOR106 was tested in two distinct in vivo models. In the calcipotriol-induced AD model, ear skin inflammation, TSLP, and IL-33 protein production in ears was suppressed by MOR106. Consistently, in the flaky tail strain mouse model, spontaneous development of AD-like skin inflammation was reduced by MOR106. Moreover, serum IgE levels, number of mast cells in skin and T helper type 2-related cytokines IL-4 and CCL17 in serum were all reduced. Overall, our results indicate that IL-17C is a central mediator of ski...Continue Reading

Citations

Aug 8, 2018·Immunotherapy·Christine Bangert, Tamara Kopp
Jan 24, 2019·Expert Opinion on Biological Therapy·Randall LiEmma Guttman-Yassky
Jun 18, 2019·Immunological Medicine·Ken Igawa
Jan 17, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Kazuhisa FurueMasutaka Furue
Jul 19, 2019·Immunological Medicine·Hiraku Suga, Shinichi Sato
Aug 10, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Eun Ji KwakMyung Hyun Sohn
Nov 26, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas Bieber
Nov 26, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas Bieber
Dec 4, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·F LaufferK Eyerich
Feb 1, 2020·Expert Opinion on Biological Therapy·Jianni Wu, Emma Guttman-Yassky
May 25, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Felix LaufferMichael P Schön
Jul 25, 2019·Allergy, Asthma & Immunology Research·Mi Seon OhMyung Hyun Sohn
Apr 24, 2020·American Journal of Clinical Dermatology·Wenelia BaghoomianEric L Simpson
Jun 27, 2020·Current Opinion in Allergy and Clinical Immunology·Fatih A TopalMaja Hofmann
Jul 9, 2020·International Journal of Molecular Sciences·Maria Maddalena SirufoMassimo De Martinis
Oct 12, 2018·International Journal of Molecular Sciences·Jolanta KlonowskaMagdalena Trzeciak
Feb 20, 2020·International Journal of Molecular Sciences·Masutaka FurueTakeshi Nakahara
Feb 6, 2020·Frontiers in Immunology·Esther von StebutAndreas Schäffler
Jul 28, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Felix LaufferMichael P Schön
May 28, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thomas Litman
Aug 22, 2018·Frontiers in Immunology·Nicolo Costantino BrembillaWolf-Henning Boehncke
Mar 17, 2020·Frontiers in Immunology·Jasper F Nies, Ulf Panzer
Dec 8, 2020·Frontiers in Immunology·Taoming LiuHong Fang
Jun 6, 2018·Current Opinion in Allergy and Clinical Immunology·Yael Renert-Yuval, Emma Guttman-Yassky
Nov 28, 2020·Frontiers in Immunology·Arianna BreviMatteo Bellone
Jan 17, 2021·The Journal of Allergy and Clinical Immunology·Yael Renert-YuvalAmy S Paller
Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus
Apr 4, 2021·The FEBS Journal·Jennifer Fan, Santosh K Mishra
Jul 3, 2021·International Journal of Molecular Sciences·Silvia VidalAntonio-Manuel Velasco-Pastor
Jul 12, 2021·The Journal of Investigative Dermatology·Jennifer L StrunckTeri M Greiling
Jul 23, 2021·Cytokine·Stephanie SwedikAlan Levine
Aug 22, 2021·Current Opinion in Immunology·Vasileios OikonomouMichail S Lionakis
Apr 24, 2019·The Journal of Investigative Dermatology·Natalie Garzorz-Stark, Kilian Eyerich
Jan 23, 2020·Actas dermo-sifiliográficas·M Munera-Campos, J M Carrascosa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jin Kyeong ChoiSang-Hyun Kim
Journal of the American Academy of Dermatology
Risa Tamagawa-MineokaNorito Katoh
© 2022 Meta ULC. All rights reserved