Neutralization of pseudotyped vesicular stomatitis virus expressing hepatitis C virus envelope glycoprotein 1 or 2 by serum from patients

The Journal of Infectious Diseases
L Martin LaggingRanjit Ray

Abstract

Infection with hepatitis C virus (HCV) generally progresses to chronic disease, although a minority of patients appear to clear viremia spontaneously. In this investigation, serum samples were analyzed for virological parameters, serum alanine aminotransferase (ALT) levels, and neutralizing antibody response against pseudotyped vesicular stomatitis virus (VSV) generated using chimeric envelope glycoprotein 1 (E1) or 2 (E2) of HCV. Testing of sequential serum samples that were collected beginning at the onset of acute-phase disease demonstrated intermittent viremia, elevated ALT levels, and detectable neutralization activity against VSV in 9 of 10 patients. Serum neutralization activity did not exhibit a correlation with the genotype of the infecting HCV or with virus load. On the other hand, patients with chronic HCV infection consistently had detectable amounts of virus present but no significant variation in ALT levels, and serum samples from a majority (>90%) of patients failed to show detectable neutralization activity.

Citations

Aug 4, 2010·The Journal of Infectious Diseases·Ranjit RayRobert B Belshe
Aug 5, 2011·Science Translational Medicine·Ranjit Ray
Dec 21, 2007·Journal of Virology·Keith MeyerRanjit Ray
May 2, 2015·Current Opinion in Virology·Leopold KongMansun Law
Jan 28, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jihua XueZhi Chen
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pavel SkumsYury Khudyakov
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan Lee RothmanUNKNOWN HALT-C Trial Group
Nov 4, 2015·World Journal of Hepatology·Jingya LyuKoji Murao

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