Neutralization of pyrogen-induced tumour necrosis factor by its type 1 soluble receptor in guinea-pigs: effects on fever and interleukin-6 release

The Journal of Physiology
J RothE Zeisberger

Abstract

1. A soluble form of the tumour necrosis factor (TNF) type 1 receptor (referred to as TNF binding protein, TNF-bp) at a dose of 1 mg per animal, or an equivalent volume of solvent, was injected together with 10 microg kg-1 lipopolysaccharide (LPS) or 50 microg kg-1 muramyl-dipeptide (MDP) directly into the arterial circulation of guinea-pigs and the effects on circulating TNF or interleukin-6 (IL-6) and on abdominal temperature were studied. 2. At 15 or 60 min after injection, LPS-induced and MDP-induced circulating TNF was below the detection limit of the assay and thus completely neutralized in animals treated with TNF-bp. In the control group, TNF was still below the limit of detection in most animals 15 min after LPS was injected; in some animals small traces of TNF could already be detected at that time. However, 60 min after administration of LPS, large amounts of TNF (19508 +/- 4682 pg ml-1) were measured in the control group. MDP-induced TNF in plasma was below the limit of detection 15 min after MDP was injected, and rose to 10862 +/- 3029 pg ml-1 60 min after injection. 3. Low levels of circulating IL-6 (20-40 international units (IU) ml-1) were measured in all groups of animals 15 min after injection of LPS or MDP. T...Continue Reading

References

Jan 1, 1991·Physiological Reviews·M J Kluger
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Oct 1, 1987·European Journal of Immunology·L A AardenP M Lansdorp
Aug 11, 1997·Pflügers Archiv : European journal of physiology·J RothE Zeisberger

❮ Previous
Next ❯

Citations

Jun 7, 2011·Medical Microbiology and Immunology·Denis M SoaresGlória E P Souza
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joon-Sup YeomJae-Won Park
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·C M Blatteis, S Li
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J B Tatro
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M BlatteisS Li
Sep 15, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sylwia WrotekWiesław Kozak
Mar 27, 2009·Physiology & Behavior·Alexandre A SteinerElaine Liu
Feb 6, 2007·Progress in Lipid Research·Alexandre A Steiner, Andrej A Romanovsky
Jul 18, 2006·Physiology & Behavior·Lois M HardenHelen P Laburn
Mar 12, 2009·Physiology & Behavior·Emilie PecchiJean-Denis Troadec
Aug 1, 2006·Neurologic Clinics·Joachim RothThomas Hübschle
Mar 22, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joachim Roth
Mar 23, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Roth, G E De Souza
Mar 29, 2011·Journal of Intensive Care Medicine·Daniel J NivenKevin B Laupland
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioGlória E P Souza
Sep 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas HübschleJoachim Roth
May 11, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea GreisJoachim Roth
Mar 22, 2014·Journal of Applied Physiology·Amanda L Bastos-PereiraAleksander R Zampronio
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annemarie LedeboerAnne-Marie Van Dam
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Thomas C VaryScot R Kimball
Dec 22, 1999·The American Journal of Physiology·S LiC M Blatteis
Apr 13, 1999·The American Journal of Physiology·R CooneyT C Vary
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph RummelJoachim Roth
Mar 19, 2013·Expert Opinion on Pharmacotherapy·Daniel J Niven, Kevin B Laupland
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexander V GourineMatthew J Kluger
Dec 14, 2017·Journal of Veterinary Emergency and Critical Care·Kris GommerenDominique Peeters
Jan 21, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jinfeng LaiAilan Qin
Apr 9, 2021·Frontiers in Pharmacology·Le-Le MaDing-Kun Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.