Neutralization of relaxin within the brain affects the timing of birth in rats

Endocrinology
A J SummerleeR S Poterski

Abstract

Experiments were performed to determine whether neutralization of relaxin in the brain, by injecting monoclonal antibodies to rat relaxin into the ventricular system of the brain, affected either the timing or the processes of birth in rats. Pregnant rats were injected daily through a chronically implanted intracerebroventricular cannula either with a specific monoclonal antibody raised against rat relaxin from days 12-22 of gestation or with an antibody raised against fluorescein as a control. The rats were watched closely from the afternoon of day 20 of pregnancy, and the process of birth was observed. No sign of dystocia was observed in any of the rats in the experiment. Neutralization of endogenous relaxin caused a significant decrease in the length of gestation (505.4 +/- 3.1 h) compared with that in rats treated with PBS (524.6 +/- 0.5 h) or that in rats treated with a nonspecific antibody (525.9 +/- 0.7 h). The time to the onset of delivery was also shorter in the relaxin-neutralized group (507.8 +/- 1.1 h) compared with that in either PBS-treated (526.5 +/- 0.6 h) or fluorescein antibody-treated (525.3 +/- 0.7 h) animals. In contrast, there was no significant effect of the relaxin antibody on length of straining, durati...Continue Reading

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Citations

Mar 10, 2010·Cellular and Molecular Life Sciences : CMLS·G E Callander, R A D Bathgate
Jun 16, 2005·Annals of the New York Academy of Sciences·Tanya C D BurazinAndrew L Gundlach
Sep 18, 2015·Reproductive Sciences·Brian W NielsenUNKNOWN Preterm Birth International Collaborative (PREBIC)
Apr 15, 2004·Endocrine Reviews·O David Sherwood
Oct 15, 2005·Endocrinology·Shu FengAlexander I Agoulnik
Jan 11, 2013·Physiological Reviews·R A D BathgateR J Summers

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