Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques

AIDS
R A RasmussenRuth M Ruprecht

Abstract

To directly examine the role of CD8+ T cells in controlling viremia and disease during chronic, low-level primate immunodeficiency virus infection in DNA prime/protein boost-vaccinated macaques. A cohort of macaques, vaccinated with either a DNA prime/HIV-1 gp160 boost regimen or with gp160 alone was previously protected partially from sequential challenges with non-pathogenic and pathogenic strains of chimeric simian/human immunodeficiency virus (SHIV). In this study, the effect of temporary ablation of CD8+ T cells in these animals was examined. Animals were treated with an anti-CD8 antibody and CD8+ T-cell levels in peripheral blood, plasma viral loads, peripheral blood mononuclear cell-associated virus levels, neutralizing antibody (nAb) titers and simian immunodeficiency virus Gag-specific CD8+ T-cell numbers were followed. Plasma viremia rose sharply in direct synchrony with a rapid but transient drop in CD8+ T cells. However, although levels of cell-associated virus also rose concomitantly, peak levels were much lower than those in virus-challenged, naive animals. In addition, despite a rise of pathogenic SHIV89.6P RNA levels in three animals, CD4+ T-cell counts remained unchanged. In each of these animals, neutralizing ...Continue Reading

References

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Citations

May 25, 2005·Veterinary Immunology and Immunopathology·Mary Jo Burkhard, Edward A Hoover
Jun 29, 2002·Current Opinion in Immunology·Flavia Ferrantelli, Ruth M Ruprecht
Aug 10, 2004·Nature Immunology·Mike RecherRolf M Zinkernagel
Mar 21, 2006·AIDS Research and Human Retroviruses·Bill G KapogiannisRama Rao Amara
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
Jun 25, 2014·Immunology and Cell Biology·Peilin LiJoseph K Wong
Sep 11, 2004·Current Opinion in Microbiology·Mike RecherKarl S Lang
Jul 15, 2009·Journal of Leukocyte Biology·Larissa Herkenhoff Haut, Hildegund C J Ertl
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yvonne M MuellerPeter D Katsikis
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·David H MargolinNorman L Letvin
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Glenn A MackayOpendra Narayan
Jan 26, 2007·The Journal of General Virology·Hiroyuki YamamotoTetsuro Matano

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