Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate.

Journal of Clinical Microbiology
Amin AddetiaA. L. Greninger


The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans. Here, we describe an outbreak of SARS-CoV-2 on a fishing vessel associated with a high attack rate. Predeparture serological and viral reverse transcription-PCR (RT-PCR) testing along with repeat testing after return to shore was available for 120 of the 122 persons on board over a median follow-up of 32.5 days (range, 18.8 to 50.5 days). A total of 104 individuals had an RT-PCR-positive viral test with a cycle threshold (CT ) of <35 or seroconverted during the follow-up period, yielding an attack rate on board of 85.2% (104/122 individuals). Metagenomic sequencing of 39 viral genomes suggested that the outbreak originated largely from a single viral clade. Only three crew members tested seropositive prior to the boat's departure in initial serological screening and also had neutralizing and spike-reactive antibodies in follow-up assays. None of the crew members with neutralizing antibody titers showed evidence of bona fide v...Continue Reading


Mar 13, 2010·PloS One·Morgan N PriceAdam P Arkin
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Mar 13, 2020·Current Protocols in Bioinformatics·Guangchuang Yu
Mar 28, 2020·MMWR. Morbidity and Mortality Weekly Report·Leah F MoriartyUNKNOWN Solano County COVID-19 Team
Apr 2, 2020·The Journal of Infectious Diseases·Nir EyalPeter G Smith
Apr 10, 2020·Journal of Clinical Microbiology·Arun K NallaAlexander L Greninger
Apr 18, 2020·Current Protocols in Microbiology·Daniel StadlbauerFlorian Krammer
Apr 27, 2020·The Journal of Infection·Yu-Lin LeePo-Ren Hsueh
Apr 30, 2020·Journal of Medical Virology·Na LiTangfeng Lv
May 6, 2020·Nature Communications·Chunyan WangBerend-Jan Bosch
May 10, 2020·Science·Seema K ShahAnnette Rid
May 10, 2020·Journal of Clinical Microbiology·Andrew BryanAlexander L Greninger
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 14, 2020·Clinical Chemistry·Mei San TangChristopher W Farnsworth
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
Jun 3, 2020·Clinical Chemistry·Mei San TangChristopher W Farnsworth
Jun 5, 2020·The Journal of Infectious Diseases·Liza DawsonJeffrey Livezey
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Adam S DingensJesse D Bloom
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·James R ByrnesJames A Wells
Jun 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ferric C FangAlexander L Greninger
Jun 12, 2020·MMWR. Morbidity and Mortality Weekly Report·Daniel C PayneBruce L Gillingham
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jun 25, 2020·BioRxiv : the Preprint Server for Biology·Eric SalazarJames M Musser
Jul 6, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Amin AddetiaAlexander L Greninger
Jul 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Linh Chi NguyenJosh Morrison
Jul 17, 2020·Nature Microbiology·Andrew RambautOliver G Pybus
Jul 30, 2020·The New England Journal of Medicine·Kizzmekia S CorbettBarney S Graham
Jul 31, 2020·Nature·Noe B MercadoDan H Barouch
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster
Aug 4, 2020·BioRxiv : the Preprint Server for Biology·Yiska WeisblumPaul D Bieniasz
Aug 4, 2020·MedRxiv : the Preprint Server for Health Sciences·Anita S IyerRichelle C Charles
Aug 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Jan Van ElslandePieter Vermeersch

❮ Previous
Next ❯


Sep 24, 2020·Nature·Florian Krammer
Oct 8, 2020·Nature Reviews. Immunology·Marc LipsitchShane Crotty
Oct 21, 2020·Nature·Christian Gaebler, Michel C Nussenzweig
Nov 5, 2020·Journal of the Royal Society, Interface·Laurent Hébert-DufresneAntoine Allard
Oct 2, 2020·The Journal of Infectious Diseases·Katharine H D CrawfordJesse D Bloom
Nov 1, 2020·The Journal of Infectious Diseases·Lisa HenssBarbara S Schnierle
Dec 15, 2020·Wiener klinische Wochenschrift·Florian DeisenhammerMarkus Reindl
Dec 30, 2020·The Journal of Infection·Aidan T HanrathChristopher J A Duncan
Dec 29, 2020·Science Immunology·Catherine J ReynoldsRosemary J Boyton
Jan 15, 2021·Open Forum Infectious Diseases·Adi V GundlapalliUNKNOWN CDC COVID-19 Response
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Feb 6, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Anna Jeffery-SmithMaria Zambon
Jan 11, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michele CarboneEnrico Bucci
Dec 19, 2020·Nature Medicine·Katie J EwerUNKNOWN Oxford COVID Vaccine Trial Group
Oct 23, 2020·Emerging Infectious Diseases·Paul K S ChanMalik Peiris
Jan 6, 2021·Nature Communications·Eric H Y LauMalik Peiris
Jan 23, 2021·Membranes·Jordana Muñoz-BasagoitiNuria Izquierdo-Useros
Feb 2, 2021·Immunobiology·Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia
Dec 20, 2020·Nature Reviews. Immunology·Lianpan Dai, George F Gao
Jan 30, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Zsolt SzépfalusiThomas Frischer
Feb 4, 2021·Signal Transduction and Targeted Therapy·Pengfei JinFengcai Zhu
Dec 23, 2020·Open Forum Infectious Diseases·Andrew BryanAlexander L Greninger
Feb 2, 2021·Best Practice & Research. Clinical Rheumatology·Bijal A Parikh, Christopher W Farnsworth
Dec 29, 2020·The New England Journal of Medicine·Sheila F LumleyUNKNOWN Oxford University Hospitals Staff Testing Group
Nov 15, 2020·Biochemical and Biophysical Research Communications·Jorge CarrilloJulià Blanco
Feb 25, 2021·JAMA Internal Medicine·Raymond A HarveyLynne T Penberthy
Oct 20, 2020·The Lancet Infectious Diseases·Rebecca C H BrownJulian Savulescu
Dec 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sridhar V BasavarajuSusan L Stramer
Mar 2, 2021·International Reviews of Immunology·Asha BhardwajRupesh K Srivastava
Mar 3, 2021·Cell Reports Medicine·Michael S PiepenbrinkJames J Kobie
Feb 22, 2021·Advanced Drug Delivery Reviews·Donald Forthal
Feb 4, 2021·The Journal of Infectious Diseases·Katharine H D CrawfordJesse D Bloom

❮ Previous
Next ❯

Methods Mentioned

enzyme-linked immunosorbent assay
serum draws

Software Mentioned

neutcurve Python

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.