PMID: 9525632Apr 3, 1998Paper

Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein

Journal of Virology
T R KreilM M Eibl

Abstract

Antibody-mediated neutralization of viruses has been extensively studied in vitro, but the precise mechanisms that account for antibody-mediated protection against viral infection in vivo still remain largely uncharacterized. The two points under discussion are antibodies conferring sterilizing immunity by neutralizing the virus inoculum or protection against the development of disease without complete inhibition of virus replication. For tick-borne encephalitis virus (TBEV), a flavivirus, transfer of neutralizing antibodies specific for envelope glycoprotein E protected mice from subsequent TBEV challenge. Nevertheless, short-term, low-level virus replication was detected in these mice. Furthermore, mice that were exposed to replicating but not to inactivated virus while passively protected developed active immunity to TBEV rechallenge. Despite the priming of TBEV-specific cytotoxic T cells, adoptive transfer of serum but not of T cells conferred immunity upon naive recipient mice. These transferred sera were not neutralizing and were predominantly specific for NS1, a nonstructural TBEV protein which is expressed in and on infected cells and which is also secreted from these cells. Results of these experiments showed that desp...Continue Reading

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Citations

Apr 2, 2004·Expert Review of Vaccines·Gwong-Jen J ChangBrent S Davis
Sep 5, 2002·Nature Reviews. Immunology·Dennis R Burton
May 13, 2008·Expert Reviews in Molecular Medicine·Theodore C Pierson, Michael S Diamond
Feb 27, 2020·Reviews in Medical Virology·Arianna Mahely Hurtado-MonzónRosa María Del Ángel
Apr 11, 2006·PLoS Pathogens·Milan LabudaPatricia A Nuttall
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Regina M KoflerChristian W Mandl
Jun 25, 2015·Frontiers in Microbiology·Ning LiSidang Liu
Jan 19, 2002·Annals of the New York Academy of Sciences·J T RoehrigC D Blair
Jun 4, 2010·The American Journal of Tropical Medicine and Hygiene·Douglas G WidmanPeter W Mason
Aug 19, 2020·Vaccines·Mareike KubinskiGuus F Rimmelzwaan
Nov 24, 2018·Frontiers in Immunology·Liana O MedinaAxel T Lehrer
Apr 9, 2021·The Journal of Experimental Medicine·Marianna AgudeloMichel C Nussenzweig

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