PMID: 13575667Sep 1, 1958Paper

Neutralizing antibodies to streptococcal diphosphopyridine nucleotidase in the serum of experimental animals and human beings

The Journal of Experimental Medicine
A KELLNERA S CARLSON

Abstract

Specific neutralizing antibodies directed against streptococcal DPNase were induced experimentally in rabbits and guinea pigs by the injection of partially purified preparations of the enzyme. Similar antibodies capable of inhibiting the biological activity of the enzyme were found to occur naturally in the serum of a very high percentage of human beings, and the titer of these antibodies often rose sharply following streptococcal infections. The antibody response to streptococcal DPNase in general paralleled that to streptolysin O, though in some instances antibodies to one increased when those to the other did not.

Citations

Oct 15, 1970·The New England Journal of Medicine·P FerrieriL W Wannamaker
Sep 1, 1969·The Journal of Clinical Investigation·B F AnthonyS S Chapman
Apr 1, 1960·Circulation·L W WANNAMAKER, E M AYOUB
Jan 1, 1971·European Journal of Biochemistry·F J Fehrenbach
May 8, 1963·Annals of the New York Academy of Sciences·S P HALBERT
May 1, 1966·Applied Microbiology·E M Ayoub, J J Ferretti

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