Neutralizing antibody response variation against dengue 3 strains

Journal of Medical Virology
Mayling AlvarezMaria G Guzman

Abstract

To evaluate the neutralizing antibody activity of a human sera panel against seven strains of the homotypic virus. Sera were collected from DENV-3 immune individuals. Two DENV-3 genotypes and strains isolated at different time-points during the 2000 and 2001-2002 Havana epidemics were included. A panel of 20 late convalescent sera collected 16-18 months after acute illness from DF and DHF patients are studied. These individuals were infected during the 2001-2002 Havana DENV-3 epidemic. All but four sera collected from DF cases had a secondary DENV-1/DENV-3 infection. Sera neutralizing antibody titer against the seven DENV-3 strains were determined by plaque reduction neutralization technique. Sera samples were tested simultaneously. Studied sera showed higher levels of neutralizing antibodies to DENV-3 strains of genotype III compared to genotype V. Interesting, higher levels of neutralizing antibodies were detected to DENV-3 strain isolated at the end of the epidemic 2001-2002. An increased tendency of GMT of neutralizing antibodies according to epidemic evolution was observed for the 2001-2002 outbreak. In general, antibody levels in sera collected from DF cases were higher. Differences in the neutralization capacity of immun...Continue Reading

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Citations

Oct 2, 2012·BMC Infectious Diseases·Kaitlin Rainwater-LovettJustin Lessler
Jul 25, 2009·Virology Journal·Alberto A AmarillaVictor H Aquino
Aug 13, 2013·BioMed Research International·Rosmari Rodriguez-Roche, Ernest A Gould
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Aug 30, 2013·Expert Review of Vaccines·Monica A McArthurRobert Edelman

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