Neutralizing Antibody Therapeutics for COVID-19.

Viruses
Aeron C Hurt, Adam K Wheatley

Abstract

The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic has resulted in a significant global public health burden, leading to an urgent need for effective therapeutic strategies. In this article, we review the role of SARS-CoV-2 neutralizing antibodies (nAbs) in the clinical management of COVID-19 and provide an overview of recent randomized controlled trial data evaluating nAbs in the ambulatory, hospitalized and prophylaxis settings. Two nAb cocktails (casirivimab/imdevimab and bamlanivimab/etesevimab) and one nAb monotherapy (bamlanivimab) have been granted Emergency Use Authorization by the US Food and Drug Administration for the treatment of ambulatory patients who have a high risk of progressing to severe disease, and the European Medicines Agency has similarly recommended both cocktails and bamlanivimab monotherapy for use in COVID-19 patients who do not require supplemental oxygen and who are at high risk of progressing to severe COVID-19. Efficacy of nAbs in hospitalized patients with COVID-19 has been varied, potentially highlighting the challenges of antiviral treatment in patients who have already progressed to severe disease. However, early data suggest a promising prophylactic role for nAbs in providing effec...Continue Reading

References

May 31, 2013·Science Translational Medicine·Maria P LimberisJames M Wilson
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew J MurphyGeorge D Yancopoulos
Nov 28, 2019·The New England Journal of Medicine·Sabue MulanguUNKNOWN PALM Consortium Study Team
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
May 24, 2020·The New England Journal of Medicine·John H BeigelUNKNOWN ACTT-1 Study Group Members
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jul 17, 2020·Annals of Internal Medicine·Caleb P SkipperDavid R Boulware
Jul 18, 2020·The New England Journal of Medicine·UNKNOWN RECOVERY Collaborative GroupMartin J Landray
Jul 24, 2020·BioRxiv : the Preprint Server for Biology·Bei WangCheng-I Wang
Jul 25, 2020·The New England Journal of Medicine·Alexandre B CavalcantiUNKNOWN Coalition Covid-19 Brazil I Investigators
Aug 22, 2020·JAMA : the Journal of the American Medical Association·Christoph D SpinnerUNKNOWN GS-US-540-5774 Investigators
Aug 25, 2020·Trends in Pharmacological Sciences·Alex RennAnton Simeonov
Sep 11, 2020·Nature Microbiology·Wen Shi LeeBrandon J DeKosky
Sep 30, 2020·Cytotherapy·Kuttuvan Valappil Sajna, Siya Kamat
Oct 1, 2020·BioRxiv : the Preprint Server for Biology·Ge SongRaiees Andrabi
Oct 6, 2020·Frontiers in Immunology·Zeinab AbdelrahmanXiaosheng Wang
Oct 10, 2020·Infection·Bernd SalzbergerFrank Hanses
Oct 22, 2020·The New England Journal of Medicine·John H StoneUNKNOWN BACC Bay Tocilizumab Trial Investigators
Oct 23, 2020·Nature Biotechnology·Laura DeFrancesco
Oct 29, 2020·The New England Journal of Medicine·Peter ChenUNKNOWN BLAZE-1 Investigators
Nov 1, 2020·Influenza and Other Respiratory Viruses·Tawee ChotpitayasunondhJohn S Tam
Nov 25, 2020·The New England Journal of Medicine·Ventura A SimonovichUNKNOWN PlasmAr Study Group
Dec 6, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sabeena AhmedWasif Ali Khan
Dec 16, 2020·MAbs·Marco TuccoriDaniele Focosi
Dec 18, 2020·The New England Journal of Medicine·David M WeinreichUNKNOWN Trial Investigators
Dec 18, 2020·The New England Journal of Medicine·Carlos SalamaShalini V Mohan
Dec 20, 2020·Nature Reviews. Immunology·Lianpan Dai, George F Gao

❮ Previous
Next ❯

Citations

Jun 17, 2021·Cancer Cell·Astha ThakkarBalazs Halmos
Aug 3, 2021·British Journal of Haematology·Paul SaultierHervé Chambost

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.