Neutron capture therapy with gadopentetate dimeglumine: experiments on tumor-bearing rats

Academic Radiology
V F KhokhlovR Lawaczeck

Abstract

The therapeutic effect of neutron capture therapy with the gadolinium (Gd) complex gadopentetate dimeglumine was studied in vivo in rats using a beam of thermal neutrons. Rats with Jensen sarcomas 10-15 mm in diameter in their right thigh were irradiated with a thermal neutron beam that had fluences of 3.6 x 10(11) (20 min) or 5.4 x 10(11) n/cm2 (30 min) in the absence and presence of 5,500 or 13,750 ppm gadopentetate dimeglumine. Gadopentetate dimeglumine was administered directly into the tumor prior to neutron irradiation. Four groups of rats were studied: two groups of nonirradiated controls (Gd-n- and Gd+n-) and two irradiated groups (Gd-n+ and Gd+n+). In the follow-up period, we measured the subjects' clinical status and tumor size as a function of time postirradiation. In both control groups (Gd-n- and Gd+n-), the tumor progressively grew. Pure irradiation by thermal neutrons in the Gd-n+ group resulted in a transient inhibition of tumor growth with total regressions of 15%. Intratumoral administration of 13,750 ppm gadolinium per gram of tumor and subsequent neutron irradiation (the Gd+n+ group; fluence = 3.6.10(11) n/cm2) significantly increased the tumoricidal effects (i.e., decrease of tumor growth up to a complete r...Continue Reading

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·Y AkineK Kanda
Sep 1, 1992·Medical Physics·J T MasiakowskiL J Peters
May 1, 1992·Medical Physics·J L Shih, R M Brugger
Oct 1, 1990·Scientific American·R F BarthR G Fairchild
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·Y AkineK Kanda

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