PMID: 8949750Jan 1, 1996Paper

Neutrons and carcinogenesis: a cautionary tale

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
E J Hall

Abstract

The best estimates for radiation induced cancer and leukemia are based on the Japanese survivors of Hiroshima and Nagasaki. With the earlier dosimetry systems of the 1960s, it was possible to drive an RBE (relative biological effectiveness) for neutrons from the Japanese data, because it was thought that there was a significant neutron dose at Hiroshima compared with Nagasaki. The estimated RBE of about 20 was consistent with laboratory estimates for oncogenic transformation in vitro and tumors in animals. The revised dosimetry of the 1980s [DS 86] essentially eliminated the neutron component at Hiroshima, and consequently removed the only neutron RBE estimate based on human data. However, recent neutron activation measurements indicate that there may indeed have been thermal neutrons at Hiroshima, and measurements of the ratio of inter- to intra-chromosomal aberrations in peripheral lymphocytes of survivors also tend to indicate that the biologically effective dose was dominated by neutrons. Another area in which the large biological effectiveness of neutrons assumes importance is the production of photoneutrons in high energy medical linear accelerators (Linacs). An increasing number of accelerators operating in the 18 to 20 ...Continue Reading

References

Apr 1, 1978·Health Physics·H H Rossi, C W Mays
May 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E J TawnG B Schofield
Apr 1, 1986·Mutation Research·J Pohl-RülingB C Das
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·E J HallT K Hei

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Citations

Dec 8, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C VautraversN Penel
Mar 14, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jao-Perng LinChun-Chih Lin
Apr 10, 2007·International Journal of Radiation Oncology, Biology, Physics·Sylvain NadeauLuc Gingras
Jul 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H EngelsA Wambersie
Mar 15, 2002·Radiation Research·Alice J SigurdsonElaine Ron
Jul 12, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Igor Shuryak

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