Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort

Cancer Medicine
Aurelia H M de Vries SchultinkJos H Beijnen

Abstract

The incidence of neutropenia in metastatic castration-resistant prostate cancer (mCRPC) patients treated with docetaxel has been reported to be lower compared to patients with other solid tumors treated with a similar dose. It is suggested that this is due to increased clearance of docetaxel in mCRPC patients, resulting in decreased exposure. The aims of this study were to (1) determine if exposure in mCRPC patients is lower vs patients with other solid tumors by conducting a meta-analysis, (2) evaluate the incidence of neutropenia in patients with mCRPC vs other solid tumors in a clinical cohort, and (3) discuss potential clinical consequences. A meta-analysis was conducted of studies which reported areas under the plasma concentration-time curves (AUCs) of docetaxel and variability. In addition, grade 3/4 neutropenia was evaluated using logistic regression in a cohort of patients treated with docetaxel. The meta-analysis included 36 cohorts from 26 trials (n = 1150 patients), and showed that patients with mCRPC had a significantly lower mean AUC vs patients with other solid tumors (fold change [95% confidence interval (CI)]: 1.8 [1.5-2.2]), with corresponding AUCs of 1.82 and 3.30 mg∙h/L, respectively. Logistic regression, in...Continue Reading

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Citations

Nov 17, 2019·Pharmaceutical Research·Marie-Rose B S CrombagAlwin D R Huitema
Nov 29, 2020·British Journal of Clinical Pharmacology·Marsilla MuthMarkus Joerger
Feb 5, 2021·Clinical Pharmacology : Advances and Applications·Marit VermuntJos Beijnen
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tamara ZwainKamalinder K Singh

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