PMID: 2494315Apr 1, 1989Paper

Neutropenia and thrombocytopenia in infants with Rh hemolytic disease

The Journal of Pediatrics
J M Koenig, R D Christensen

Abstract

To assess the incidence and mechanisms of thrombocytopenia and neutropenia in neonates with Rh hemolytic disease, we studied 20 consecutive patients with this condition who were born at our hospital. All five patients with severe disease (hydrops) had neutropenia and thrombocytopenia before and after exchange transfusions. Two of six patients with moderately severe disease (not hydropic but requiring exchange transfusion) had neutropenia; all six had thrombocytopenia. Of nine patients with mild disease (not treated with exchange transfusions), two had neutropenia but none had thrombocytopenia. The mean platelet volume was low or normal (7.5 +/- 0.2 ft) in the patients with thrombocytopenia, and the neutropenia was not accompanied by a "left shift" (ratio of immature to total neutrophils 0.26 +/- 0.03, mean +/- SEM). In two severely affected patients, erythroid progenitor levels were elevated and their proliferative rates (tritiated thymidine suicide) were increased, whereas their granulocyte-macrophage progenitor levels and the proliferative rates of those progenitors were diminished. In a severely affected patient, the in vitro maturation of multipotent progenitors was altered, with production of a greater than normal proporti...Continue Reading

References

Jan 1, 1988·Developmental Biology·A R Migliaccio, G Migliaccio
Feb 1, 1971·Archives of Disease in Childhood·J M Chessells, J S Wigglesworth
Nov 1, 1982·The Journal of Pediatrics·S L Kipper, L Sieger
Jan 1, 1981·The Journal of Pediatrics·R D ChristensenG Rothstein

❮ Previous
Next ❯

Citations

Nov 20, 2002·Journal of Pediatric Hematology/oncology·Frank Pessler, David Hart
Apr 1, 1994·British Journal of Obstetrics and Gynaecology·B ThilaganathanK H Nicolaides
Apr 1, 1992·Archives of Disease in Childhood·N P DaviesK H Nicolaides
Nov 15, 2000·The Journal of Perinatal & Neonatal Nursing·K M Horns
May 29, 2012·Early Human Development·A Del Vecchio, R D Christensen
Jan 1, 1990·Transfusion Medicine Reviews·R D Christensen
Jul 2, 2011·Pediatric Blood & Cancer·Esther Blanco, Donna L Johnston
Aug 1, 1989·The Journal of Pediatrics·J M KoenigR D Christensen
Jun 9, 2004·Clinics in Perinatology·Joyce M Koenig, Mervin C Yoder
May 11, 2000·Blood Reviews·S J Urbaniak, M A Greiss
May 16, 2017·Expert Review of Hematology·Isabelle M C ReeEnrico Lopriore
Feb 3, 2015·Therapeutic Advances in Hematology·Piero Farruggia, Carlo Dufour
Aug 31, 1989·The New England Journal of Medicine·J M Koenig, R D Christensen
Nov 2, 2019·World Journal of Clinical Cases·Shao-Hua BiRu-Jeng Teng
Jan 1, 1992·Platelets·C KaplanG Tchernia
May 11, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Joshua I RosenbloomAlison G Cahill
Feb 1, 1992·American Journal of Hematology·R D Christensen, G Rothstein
Oct 4, 2000·Pediatrics·S A OmarP K Alsgaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.