Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2)

Agents and Actions
G CamussiF Bussolino

Abstract

Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.

References

Aug 1, 1983·Agents and Actions·H Bult, A G Herman
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Feb 1, 1989·The Journal of Clinical Investigation·J S WarrenP A Ward
Jul 8, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E B LoucksA K Qayumi
Feb 1, 1986·American Journal of Hematology·A C Issekutz, M Ripley

Citations

Related Concepts

Thrombocytopenia
Neutrophil Band Cells
Neutropenia
Platelet Aggregation Measurement
Aggregation
Chromatography
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Flolan
Absolute Neutrophil Count
Soluble

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