PMID: 9187516Feb 1, 1997Paper

Neutrophil- and glutathione-mediated hepatotoxicity of alpha-naphthylisothiocyanate

Drug Metabolism Reviews
Robert A Roth, L J Dahm

Abstract

In summary, both glutathione and blood neutrophils contribute to ANIT hepatotoxicity. Glutathione contributes by virtue of its ability to form a reversible S-conjugate with ANIT that is critical in shuttling ANIT into bile. Where it is released in large and probably toxic concentrations. The possibility remains that this conjugate may be bioactivated by secondary mechanisms, but no evidence for a toxic glutathionyl conjugate of ANIT currently exists. Neutrophils and platelets both appear to play important roles in ANIT hepatotoxicity. The role of platelets is currently unknown, but studies in vitro raise the possibility that neutrophils may be activated during ANIT exposure to release cytotoxic proteases that cause injury to target cells. Although ANIT activates neutrophils in vitro, the mechanisms by which neutrophils are recruited into the periportal region and activated in vivo remain unknown.

References

Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P Nolan
Aug 1, 1988·Toxicology and Applied Pharmacology·L J DahmR A Roth
Oct 1, 1974·Experimental and Molecular Pathology·S LockG L Plaa
Jun 1, 1974·Chemico-biological Interactions·G M Williams
Jul 1, 1970·Toxicology and Applied Pharmacology·F Capizzo, R J Roberts
Jun 1, 1971·Toxicology and Applied Pharmacology·F Capizzo, R J Roberts
Jun 26, 1995·Toxicology·M B BailieR A Roth
Sep 1, 1995·Toxicology and Applied Pharmacology·M B BailieR A Roth
Jan 18, 1995·Biochemical Pharmacology·P A JeanR A Roth
Dec 1, 1994·Toxicology and Applied Pharmacology·M B BailieR A Roth
Dec 1, 1962·The American Journal of Medicine·H POPPERF SCHAFFNER

❮ Previous
Next ❯

Citations

Jan 4, 2019·American Journal of Veterinary Research·Alyssa M ChandlerKaren L Warner
Oct 31, 2018·International Journal of Molecular Sciences·Kimitaka TakitaniHiroshi Tamai
Feb 16, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ying ZhaoQiaoling Yu
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·James P LuyendykRuipeng Wang
Feb 15, 2019·Clinical and Translational Science·Paul B Watkins
Oct 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Lela Stefanovic, Branko Stefanovic
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Hiroko KuriharaHajime Takikawa
Jul 10, 2010·Toxicologic Pathology·Brenda FaiolaJohn M Cullen
May 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Tadashi NakamuraNobuhiro Harada
Apr 17, 2003·Archives of Toxicology·T Andrew ClaytonJeremy K Nicholson
Nov 19, 2003·The Journal of Clinical Investigation·Yaping LiuStacey A Jones
Nov 19, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bradley P SullivanJames P Luyendyk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.