PMID: 7544688Jun 1, 1995Paper

Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass

Cardiovascular Research
W J DreyerK L Berens

Abstract

The aim was to determine whether, in a canine model, changes in surface expression of the neutrophil adhesion molecules CD11b/CD18 and L-selectin during and after open heart surgery with cardiopulmonary bypass can be used to identify subjects at risk for postoperative pulmonary dysfunction. Adult mixed breed dogs underwent cardiopulmonary bypass and were compared to "sham bypass" controls. Flow cytometry was performed on blood from the two groups of dogs and changes in CD11b/CD18 adhesion molecules and L-selectin were investigated. Flow cytometry on blood from bypass dogs showed increased CD18 expression during and after cardiopulmonary bypass and a reciprocal decrease in L-selectin expression. Sham animals showed no significant change. In the bypass animals, changes in adhesion molecule expression were not evenly distributed across the population of circulating neutrophils; however, they were indicative of a percentage of activated cells. There was a significant negative linear relationship between the percentage of activated cells and arterial oxygenation 3 h after bypass (r = -0.80, P < 0.001). From this analysis, 11 animals were identified as "high" responders and seven as "low" responders, with different patterns of cellul...Continue Reading

Citations

Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T HurstI Mayers
Jun 17, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P BugajskiT Siminiak
Aug 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·Y J GuW van Oeveren
Apr 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·I MayersM W Radomski
Apr 16, 1998·The Journal of Thoracic and Cardiovascular Surgery·W J DreyerG L Kukielka
May 1, 1996·The British Journal of Surgery·M D Menger, B Vollmar
Oct 8, 1999·Journal of Cardiovascular Pharmacology·D NyhanN Flavahan
Aug 24, 1999·Perfusion·G Asimakopoulos

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