Abstract
Total cardiopulmonary bypass, in an ovine model, is associated with increased pulmonary thromboxane A2 production, cellular sequestration of white cells and platelets, transient pulmonary hypertention, and increased lung lymph flow and lymph protein clearance when compared with respective findings with partial cardiopulmonary bypass. This study evaluates the effect of neutrophil adhesion blockade on lung injury after cardiopulmonary bypass. Two groups of anesthetized sheep were placed on total cardiopulmonary bypass without assisted ventilation. One group of seven sheep was treated before and during total cardiopulmonary bypass with the neutrophil adhesion blocker NPC 15669. A second group of seven sheep did not receive NPC 15669 treatment before total cardiopulmonary bypass. A third group of seven sheep was treated with NPC 15669 before initiation of partial cardiopulmonary bypass with continued assisted ventilation. Aortic occlusion and hypothermia were not used. After 90 minutes all sheep were separated from cardiopulmonary bypass, with resumption of assisted ventilation and pulmonary arterial flow. After 30 minutes the left atrial pressure was elevated mechanically. Hemodynamics, thromboxane A2 levels, platelet levels, and ...Continue Reading
References
Mar 1, 1992·Immunopharmacology·J M BatorR M Burch
Apr 1, 1991·Circulation Research·G GoldmanH B Hechtman
Dec 1, 1989·Circulation·M R LittL C Becker
Oct 1, 1984·Circulation·P J Cannon
Jan 1, 1994·The Annals of Thoracic Surgery·A M GillinovA Herskowitz
Nov 1, 1993·The Annals of Thoracic Surgery·W E CurtisT J Gardner
Citations
Mar 10, 2001·The Annals of Thoracic Surgery·G LiW Luo
May 7, 1998·European Journal of Pharmacology·P A Henricks, F P Nijkamp
Oct 24, 2003·The Journal of Surgical Research·Tanveer A KhanFrank W Sellke
Oct 29, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A RahmanM K Bayar
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J MartinF Beyersdorf
Jul 20, 2002·Anesthesiology·John G LaffeyDavy C H Cheng
Nov 21, 1997·Critical Care Medicine·G M Matuschak
May 29, 2004·Shock·John J BatesDonal J Buggy
Jan 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Oliver J WarrenThanos Athanasiou
Mar 29, 2000·The Annals of Thoracic Surgery·T SuzukiI Kashima
Jul 6, 2000·The Annals of Thoracic Surgery·R A BronickiT P Green
Oct 6, 1999·The Annals of Thoracic Surgery·G AsimakopoulosK M Taylor
Apr 24, 1999·The Annals of Thoracic Surgery·P J ChaiR M Ungerleider
Jan 6, 2001·The American Journal of Pathology·G Matute-BelloW C Liles
May 20, 1998·The Journal of Surgical Research·A StamlerR G Johnson
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SuzukiT Fukuda
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Enrico ZupancichV Marco Ranieri
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F W Sellke
Feb 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V L SerebruanyP A Gurbel
Aug 5, 2010·Interactive Cardiovascular and Thoracic Surgery·Broadus Zane AtkinsAndrea J Carpenter
Aug 24, 1999·Perfusion·G Asimakopoulos
Jun 15, 2013·Journal of Leukocyte Biology·Hjalmar R BoumaFrans G M Kroese
Aug 12, 1998·The American Journal of Physiology·K TakeyamaJ A Nadel