PMID: 3555014May 1, 1987

Neutrophil and monocyte alterations in chronic dialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S L Lewis, D E Van Epps


Chronic renal failure patients maintained on dialysis have an increased risk for infection. This article summarizes research that has been done on the function of neutrophils (PMNs) and monocytes from chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. The studies involving the HD patients showed that there is a decreased PMN in vitro chemotactic response, decreased C5a receptors on both PMNs and monocytes, and decreased oxidative metabolic responses of PMNs and monocytes to the chemotactic stimuli C5a and formyl-met-leu-phe (fMLP), but not to nonchemotactic factors. The results of studies involving phagocytosis have been conflicting and are discussed in this paper. Due to the basic principles of peritoneal dialysis, this treatment approach depletes the peritoneum of phagocytic cells, adversely affects the function of peritoneal WBCs, dilutes the existing opsonins, and alters the physiologic environment of the peritoneal cavity. Studies of peripheral PMN and monocyte function in CAPD patients have shown that, similar to HD patients, they also have decreased C5a receptors and decreased oxidative metabolic responses to the chemotactic factors C5a and fMLP. Although the factors contributing to ...Continue Reading


May 1, 1979·Annals of Internal Medicine·J W AgarP G Pletka
Jan 1, 1979·Nephron·L E Lespier-DexterM Martinez-Maldonado
Jul 1, 1978·Journal of Clinical Pathology·O FakhriA M Al-Rawi
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·W F KeaneL Raij
Feb 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P K PetersonW F Keane
Feb 1, 1986·Artificial Organs·S Ringoir, R Vanholder
Jan 1, 1986·American Journal of Nephrology·A K Cheung, L W Henderson
Jan 1, 1986·American Journal of Nephrology·S L LewisD E Chenoweth
Nov 1, 1972·The American Journal of the Medical Sciences·J Z MontgomerieL B Guze
May 15, 1973·Experientia·J H Chretien, V F Garagusi
Jan 1, 1968·Medicine·J Z MontgomerieL B Guze
Jul 1, 1983·The Journal of Clinical Investigation·C A DahindenT E Hugli
Jan 1, 1984·Scandinavian Journal of Urology and Nephrology·K HuttunenA Tiilikainen
Dec 1, 1983·Kidney International·A AmadoriM Ricci
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Sep 1, 1981·Archives of Internal Medicine·G PeresecenschiZ H Spirer
Jun 1, 1980·The Journal of Cell Biology·S J Sullivan, S H Zigmond
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka


Oct 1, 2005·Rheumatology International·Ami SchattnerOren Zimhony
Oct 20, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Krzysztof Laudański, Zbigniew Nowak
Feb 13, 2001·Kidney International. Supplement·A R RosenkranzR Oberbauer
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A FriedlanderE A Rich
Nov 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J L MegeM Olmer
Feb 1, 1990·Kidney International·R Hakim
Feb 1, 1989·Kidney International·D RoccatelloA Amore
Mar 1, 1996·Kidney International·S HeidenreichB Harrach
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R DeicherWalter H Hörl
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshinaga OtakiYoshihiro Takamitsu
Mar 23, 2006·Seminars in Dialysis·Orfeas LiangosB L Jaber
Dec 10, 1991·Clinical Materials·R Vanholder
May 1, 1996·The Journal of Laboratory and Clinical Medicine·R J JohnsonD E Van Epps
Jul 13, 2001·Infectious Disease Clinics of North America·V R Minnaganti, B A Cunha
Aug 9, 2006·Seminars in Dialysis·Michel Chonchol
Jun 21, 2014·Hemodialysis International·Lung-Wen TsaiChien-Tsai Liu
Sep 1, 1992·Kidney International·A P HaynesA G Morgan
Feb 13, 2001·Kidney International. Supplement·B L JaberB J Pereira
Jan 11, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerald CohenWalter H Hörl
Jan 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J U Leititis, M Brandis
Jan 1, 1991·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·H Schiffl, T Strasser
Nov 23, 2010·Plastic and Reconstructive Surgery·Sou-Hsin ChienJen-Pi Tsai
May 8, 2000·Indian Journal of Pediatrics·A Moudgil, A Bagga
Feb 12, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Po-Hua HuangWei-Hsiu Hsu
Oct 31, 1991·Klinische Wochenschrift·T Strasser, H Schiffl
Feb 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Oguz KaraeminogullariReha N Tandogan
Mar 20, 2013·Nature Reviews. Nephrology·Michiel G H Betjes
Oct 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Dec 1, 1992·Artificial Organs·A TridonG Betail
Sep 6, 2002·Renal Failure·Feng-Rong ChuangMai-Szu Wu
Jan 1, 1990·Biomaterials, Artificial Cells, and Artificial Organs·H Schiffl, T Strasser

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