PMID: 8613609Mar 15, 1996Paper

Neutrophil and platelet activation at balloon-injured coronary artery plaque in patients undergoing angioplasty

Journal of the American College of Cardiology
F J NeumannA Schömig

Abstract

This study sought to investigate changes in the expression of activation-dependent adhesion receptors on neutrophils and platelets after exposure to the balloon-injured coronary artery plaque. Activation of blood cells at the balloon-injured coronary artery plaque may contribute to abrupt vessel closure and late restenosis after percutaneous transluminal coronary angioplasty. In 30 patients undergoing elective coronary angioplasty, blood specimens were obtained through the balloon catheter proximal to the plaque before dilation and distal to the plaque after dilation. Simultaneous blood samples obtained through the guiding catheter served as control samples. Total surface expression of the inducible fibrinogen receptor (CD41) and surface expression of the activated fibrinogen receptor (LIBS1) on platelets as well as Mac-1 (CD11b) and L-selectin (CD62L) surface expression on neutrophils were assessed by flow cytometry. After exposure to the dilated coronary artery plaque, surface expression of LIBS1 on platelets increased by 40.5 +/- 11.0 mean (+/-SE) fluorescence (p=0.001) and that of CD11b on neutrophils increased by 20.1 +/- 4.4 mean fluorescence (p=0.018). Concomitantly, anti-CD62L binding on neutrophils decreased by 6.6 +/-...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R E ScharfL A Harker
Dec 23, 1992·JAMA : the Journal of the American Medical Association·R C Bone
May 1, 1991·Journal of the American College of Cardiology·J H IpJ H Chesebro
Jul 1, 1990·Circulation·S De ServiG Specchia
Feb 1, 1990·The American Journal of Cardiology·P BarathJ S Forrester
Sep 1, 1986·Journal of Cellular Physiology·R BiziosA B Malik
Aug 13, 1981·The New England Journal of Medicine·P C BlockJ T Fallon
Jul 1, 1994·Journal of the American Society of Nephrology : JASN·M P GawazS K Mujais
Aug 18, 1994·The New England Journal of Medicine·G LiuzzoA Maseri
Aug 18, 1994·The New England Journal of Medicine·R W Alexander
Dec 1, 1993·Circulation·C M GasperettiE R Powers
Aug 1, 1993·Circulation·M L Entman, C M Ballantyne

❮ Previous
Next ❯

Citations

May 3, 2013·Cardiovascular and Interventional Radiology·Charles R Tapping, Mark J Bratby
Apr 13, 2006·European Radiology·Dimitrios TsetisAnna-Maria Belli
Apr 28, 2000·International Journal of Clinical & Laboratory Research·M CapanniG F Gensini
Feb 3, 2005·Current Atherosclerosis Reports·Douglas E Drachman, Daniel I Simon
Jun 15, 2004·International Journal of Cardiology·M J LeckieTrevor T Hansel
Feb 22, 2001·International Journal of Cardiology·N T MulvihillP A Crean
Feb 6, 1999·Journal of the American College of Cardiology·J K MickelsonC W Smith
Oct 11, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus H C RichterHans Georg Olbrich
Aug 24, 2005·Antioxidants & Redox Signaling·Andreas Schober, Christian Weber
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·C RogersD I Simon
Dec 31, 1998·In Vitro Cellular & Developmental Biology. Animal·W E DaleE H Blaine
Jun 15, 2011·Pharmacology & Therapeutics·Michelle J ButlerStephen J Duffy
Oct 5, 2011·Cardiovascular Therapeutics·Kailash Prasad
Oct 6, 2000·The American Journal of Cardiology·J L OrfordC Rogers
Nov 13, 2001·The American Journal of Cardiology·W KochA Kastrati
Sep 28, 2005·European Journal of Pharmacology·Masamitsu ShimazawaKazuo Umemura
Sep 6, 2005·European Journal of Pharmacology·Masamitsu ShimazawaKazuo Umemura
Jul 19, 2005·Journal of the American College of Cardiology·Teruo InoueKoichi Node
Mar 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J BaraniB Lindblad
Jan 4, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P DanielssonL Norgren
May 19, 2006·Mayo Clinic Proceedings·Gregg W Stone, Herbert D Aronow
Jul 1, 2004·Expert Review of Cardiovascular Therapy·Paul A GurbelUdaya Tantry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.