PMID: 8982038Dec 1, 1996Paper

Neutrophil apoptosis is delayed by the diadenosine polyphosphates, Ap5A and Ap6A: synergism with granulocyte-macrophage colony-stimulating factor

British Journal of Haematology
L GasmiS W Edwards

Abstract

In addition to ATP, platelets and other cell types can secrete high quantities of diadenosine polyphosphates Ap3A, Ap4A, Ap5A and Ap6A. There is increasing evidence to show that these molecules can function as novel modulators of cell function. For this report we have measured the effects of the diadenosine polyphosphates Ap5A and Ap6A on neutrophil apoptosis. These molecules can themselves delay neutrophil apoptosis (as assessed by morphology, function. CD16 expression and chromatin integrity), and are as effective on a molar basis as ATP, Ap3A and Ap4A. Moreover, these dinucleotides act synergistically with granulocyte-macrophage colony-stimulating factor (GM-CSF) to delay neutrophil apoptosis. Thus, diadenosine polyphosphates may act, in concert with cytokines, as novel modulators of neutrophil function and survival in certain types of inflammatory conditions.

Citations

Jun 1, 1997·Mechanisms of Ageing and Development·T FülöpG Dupuis
Sep 29, 2000·Pharmacology & Therapeutics·A G McLennan
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchepersRaymond Vanholder
Sep 3, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Boris K PliyevValery G Savchenko
Jul 19, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cara GearyWard Rice

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