Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Elzbieta PluskotaEdward F Plow

Abstract

Neutrophils undergo spontaneous apoptosis, but their survival can be extended during inflammatory responses. alpha(M)beta(2) is reported either to delay or accelerate neutrophil apoptosis, but the mechanisms by which this integrin can support such diametrically opposed responses are poorly understood. The abilities of closely related alpha(M)beta(2) ligands, plasminogen and angiostatin, derived from plasminogen, as well as fibrinogen and its two derivative alpha(M)beta(2) recognition peptides, P1 and P2-C, differed markedly in their effects on neutrophil apoptosis. Plasminogen, fibrinogen, and P2-C suppressed apoptosis via activation of Akt and ERK1/2 kinases, while angiostatin and P1 failed to activate these prosurvival pathways and did not prevent neutrophil apoptosis. Using cells transfected with alpha(M)beta(2) or its individual alpha(M) or beta(2) subunits, and purified receptors and its constituent chains, we show that engagement of both subunits with prosurvival ligands is essential for induction of the prosurvival response. Hence, engagement of a single integrin by closely related ligands can induce distinct signaling pathways, which can elicit distinct cellular responses.

References

Sep 21, 1991·Lancet·J M GriggM Silverman
Jun 1, 1996·The Journal of Cell Biology·M Chrzanowska-Wodnicka, K Burridge
Jul 17, 1998·Experimental Cell Research·M J O'Mullane, M S Baker
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J B KleinK R McLeish
May 10, 2000·The Journal of Biological Chemistry·E S HarrisG A Zimmerman
Oct 18, 2000·The Journal of Biological Chemistry·J P XiongM A Arnaout
Oct 26, 2000·Nature·M O Hengartner
Mar 10, 2001·Blood·B H HorwitzC M Doerschuk
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrizia ScapiniMarco A Cassatella
Aug 1, 2002·The Journal of Biological Chemistry·Felizabel Garcia BannachLindsey A Miles
Dec 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Motomu ShimaokaTimothy A Springer
Dec 20, 2002·Nature·Carl Nathan
Feb 22, 2003·The Journal of Biological Chemistry·Charito BuensucesoSanford J Shattil
Mar 21, 2003·Journal of Cellular Biochemistry·Xavier HouardMaurice Pagano
May 6, 2003·European Journal of Immunology·Carolina RubelMarina S Palermo
Dec 31, 2003·The Journal of Biological Chemistry·Patrick RossignolEduardo Anglés-Cano
Jan 27, 2004·Journal of Leukocyte Biology·C D GarlichsW G Daniel
Feb 11, 2004·The Journal of Biological Chemistry·Elzbieta PluskotaEdward F Plow
Jun 4, 2004·The Journal of Biological Chemistry·Saori SatoTakashi Tsuruo
Sep 24, 2004·Blood·Triantafyllos ChavakisKlaus T Preissner
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·S J BusuttilE F Plow
Oct 16, 2004·The Journal of Biological Chemistry·Dmitry A SolovjovEdward F Plow
Dec 22, 2004·The Journal of Cell Biology·Minsoo KimTimothy A Springer
Jun 1, 2005·Trends in Immunology·Tanya N Mayadas, Xavier Cullere
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mélanie R Tardif, Michel J Tremblay

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Citations

Jan 16, 2009·Journal of Translational Medicine·Adriana AlbiniDouglas M Noonan
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhi-Hong XueSuet-Mien Tan
Oct 1, 2011·Seminars in Ophthalmology·John L Clements, Reza Dana
Nov 5, 2011·The Journal of Biological Chemistry·Geok-Lin ChuaSurajit Bhattacharjya
Dec 4, 2013·Cell and Tissue Research·Gurpreet K AulakhBaljit Singh
Oct 19, 2019·Stem Cell Research & Therapy·Julia M KröpflChristina M Spengler
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janesh PillayLeo Koenderman
Sep 23, 2009·Current Opinion in Hematology·Angelo A ManfrediNorma Maugeri
Nov 20, 2014·International Journal of Molecular Sciences·Miroslava DidiasovaDariusz Zakrzewicz
Dec 22, 2015·Cellular & Molecular Immunology·Zhou ZhouBin Gao
Apr 4, 2021·International Journal of Molecular Sciences·Anne-Marije HulshofHugo Ten Cate
Feb 22, 2011·Trends in Cardiovascular Medicine·Riku DasEdward F Plow

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