PMID: 9544899Apr 17, 1998Paper

Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection

The Journal of Pediatrics
E WeirichL A Herzenberg

Abstract

To determine whether neutrophil surface expression of CD11b predicts early-onset infection or suspected infection in at-risk infants. CD11b expression on peripheral blood neutrophils was determined by flow cytometry of whole blood samples. Blood (0.1 ml) was obtained from a convenience sample of at-risk infants admitted to the neonatal intensive care unit, stained with antibodies detecting CD11b and CD15, chilled, and analyzed within 8 hours. Blood for culture, blood counts, and C-reactive protein (CRP) determination was obtained simultaneously. Subjects were grouped on the basis of culture results and clinical signs, and investigators were blinded to CD11b level. Of 106 subjects, seven had positive bacterial or viral cultures ("confirmed infection"), 17 had clinical signs of infection but negative cultures ("suspected infection"), and 82 had negative cultures and no clinical signs ("no infection"). Neutrophil CD11b was elevated in all infants with confirmed infection, 94% with suspected infection, and none with no infection. The negative and positive predictive values, sensitivity, and specificity were 100%, 99%, 96%, and 100%, respectively, for diagnosis of neonatal infection at initial evaluation. CD11b levels correlated wit...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·E A FreyS D Wright
Apr 1, 1992·The Journal of Pediatrics·N Y Schouten-Van MeeterenF Van Bel
May 1, 1988·The Journal of Pediatrics·R L RodwellD I Tudehope
Sep 1, 1995·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·M Crockett
Mar 1, 1994·FEMS Immunology and Medical Microbiology·N Rebuck, A Finn
May 1, 1995·The Journal of Infectious Diseases·A H FroonW A Buurman
May 1, 1995·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P G Holt
Sep 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·M WilliamsonM Tilse
May 1, 1995·The Pediatric Infectious Disease Journal·O Da SilvaC Kenyon
Jul 21, 1995·Annals of the New York Academy of Sciences·K DrewsA Mackiewicz
May 1, 1993·Journal of Leukocyte Biology·R WeingartenP S Tobias
Jan 1, 1995·Paediatric and Perinatal Epidemiology·M GermainJ R Daling
Jun 1, 1995·The Journal of Pediatrics·M L SpearR Proujansky
Aug 1, 1994·Biochemical Society Transactions·E J Pettit, M B Hallett
Mar 1, 1995·The Journal of Pediatrics·C R Rosenfeld
Dec 1, 1994·Pediatric Research·R L RobertsE R Stiehm
May 1, 1993·The Pediatric Infectious Disease Journal·R L RodwellP H Gray
Sep 15, 1993·Journal of Immunological Methods·H RepoM Leirisalo-Repo
Apr 1, 1993·Current Opinion in Pediatrics·A Ohlsson, J Lacy
Aug 1, 1993·American Journal of Respiratory Cell and Molecular Biology·A WollnerJ B Smith
Jul 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H R SalzerW Schemper
Feb 1, 1996·Obstetrics and Gynecology·M K YanceyB H Frentzen
Apr 1, 1996·The Journal of Pediatrics·D GendrelC Bohuon

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Citations

May 26, 1999·Infectious Disease Clinics of North America·C Parent, P Q Eichacker
Jan 4, 2001·International Journal of Antimicrobial Agents·I C Gyssens
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C Ng
Apr 25, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·U K MishraS M Garland
Oct 16, 1999·Archives of Disease in Childhood·M HatherillI A Murdoch
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P BallabhS Cunningham-Rundles
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·B W KramerM Ikegami
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Atsuyasu SatoMachiko Ikegami
May 6, 2003·American Journal of Respiratory Cell and Molecular Biology·Susan M GerikFrank C Schmalstieg
May 17, 2011·Journal of Global Infectious Diseases·Usama M AlkholiMohamed H Sultan
Jun 1, 2007·Biomarkers in Medicine·Hugh S Lam, Pak C Ng
Jun 4, 2013·European Journal of Pediatrics·Josko MarkicVedrana Cikes Culic
Jan 12, 2016·Pediatrics and Neonatology·Francesca CorteseMarco Matteo Ciccone
Sep 4, 2010·Clinics in Perinatology·Pak C Ng, Hugh S Lam
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joris R Delanghe, Marijn M Speeckaert
Mar 26, 2011·Journal of Clinical Laboratory Analysis·Joel JämsäTero Ala-Kokko
Jul 19, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jens VikseJerzy A Walocha
Nov 5, 2013·Virulence·Birju A Shah, James F Padbury
Dec 19, 2014·Scandinavian Journal of Infectious Diseases·Sofie Sommer HedegaardAnne-Mette Hvas
Apr 22, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaPradeep Sharma
May 2, 2007·Current Opinion in Infectious Diseases·Jari Nuutila, Esa-Matti Lilius
Apr 19, 2005·Expert Review of Molecular Diagnostics·Dimitris A KafetzisChristos Costalos
Apr 19, 2005·Expert Review of Molecular Diagnostics·Bruce H Davis
Oct 29, 2003·Paediatric Drugs·Robert S Baltimore
Mar 5, 2019·Virulence·Sona SarmirovaShubhada Bopegamage
Mar 7, 2002·Journal of Pediatric Hematology/oncology·R K OhlsL C Sklar
Dec 12, 2018·Cellular Microbiology·Nancy CharoRicardo M Gómez
May 21, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ondrej SoucekCtirad Andrys
Apr 23, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·James L WynnRichard A Polin
Nov 15, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Esther Layseca-EspinosaRoberto González-Amaro
Jan 1, 2007·Acta Medica (Hradec Králové)·Pavel RozsívalCtirad Andrýs
Oct 16, 2019·Frontiers in Pediatrics·Hassan O EliwanEleanor J Molloy
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian A MaungJames A Lederer
Oct 6, 2007·Scandinavian Journal of Infectious Diseases·Karlis PauksensPer Venge

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