PMID: 3762132Sep 1, 1986Paper

Neutrophil chemiluminescence and opsonic fibronectin levels following blunt trauma

The Journal of Surgical Research
M E LanserJ H Siegel

Abstract

Trauma is known to result in depression of opsonic fibronectin levels as well as abnormalities in neutrophil function. Neutrophil oxidative metabolism, important for bactericidal activity, has not been investigated following injury. Since fibronectin has been reported to increase neutrophil chemiluminescence (CL), we examined the relationship between neutrophil oxidative metabolism (as measured by chemiluminescence) and opsonic fibronectin levels following blunt trauma. Sera from 11 nonseptic and 9 eventually septic-trauma patients were studied. Normal neutrophils incubated in septic-trauma serum had decreased CL responses compared to incubation in nonseptic serum (P less than 0.0001). This difference was apparent immediately after injury, prior to the onset of sepsis. This depression was due to the presence of a serum suppressor of neutrophil chemiluminescence and not to the absence of a serum factor. This suppressor has been partially characterized as a protein of greater than 30,000 Da. Opsonic fibronectin levels were also depressed in septic-trauma sera compared to nonseptic-trauma sera (P less than 0.0001). However, no correlation could be demonstrated between the CL response and opsonic fibronectin levels. Addition of fib...Continue Reading

References

Dec 1, 1978·American Journal of Surgery·A R BauerJ D Mason
Apr 1, 1979·The Journal of Surgical Research·N V Christou, J L Meakins
Mar 8, 1976·Biochemical and Biophysical Research Communications·R C Allen, L D Loose
Feb 1, 1986·Archives of Surgery·M E LanserJ H Siegel
Mar 1, 1974·Annals of Surgery·S C SchimpffR B Hornick
Sep 1, 1968·Annals of Surgery·J W AlexanderW A Altemeier
Mar 1, 1984·The Journal of Trauma·J L Ninnemann, A E Stockland
Feb 1, 1982·Clinical Immunology and Immunopathology·T D HoranT A McPherson

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