PMID: 8942140Jan 1, 1996Paper

Neutrophil chemotactic activity in cryptogenic organizing pneumonia and the response to erythromycin

The Kurume Medical Journal
M Hotta

Abstract

The present study was aimed at elucidating the role of inflammatory cells in the pathogenesis of cryptogenic organizing pneumonia, and the mode of action of erythromycin in inhibiting the progression of the disease. Bronchoalveolar lavage fluid was obtained from 16 patients with cryptogenic organizing pneumonia and 4 control subjects. Neutrophil chemotactic activity was determined in relation to the concentration of two cytokines, interleukin-8 and tumor necrosis factor-alpha. Eight patients with cryptogenic organizing pneumonia, 4 with bronchoalveolar lavage fluid neutrophilia and 4 without, received low dose oral erythromycin daily (600 mg) for 2 to 3 months. Bronchoalveolar lavage fluid was obtained before and after treatment. In the bronchoalveolar lavage fluid of cryptogenic organizing pneumonia patients with bronchoalveolar lavage fluid neutrophilia, the levels of neutrophil chemotactic activity, interleukin-8, and tumor necrosis factor-alpha were significantly increased compared with levels measured in control subjects and in cryptogenic organizing pneumonia patients without bronchoalveolar lavage fluid neutrophilia. The level of interleukin-8 correlated with the percent of neutrophils and neutrophil chemotactic activity...Continue Reading

Citations

Oct 12, 2005·Current Allergy and Asthma Reports·Umur Hatipoglu, Israel Rubinstein
Nov 8, 2001·European Journal of Pharmacology·O CulićM J Parnham
Sep 19, 2003·European Journal of Internal Medicine·A Van MeerhaegheP Brasseur
Oct 30, 2012·Immunology and Allergy Clinics of North America·Keith C Meyer, Jennifer Bierach
Nov 1, 2006·Revue de pneumologie clinique·M LangelotP Germaud
Dec 8, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Paola FaverioAlberto Pesci

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