PMID: 6406587Jul 1, 1983Paper

Neutrophil chemotactic activity in milk-induced asthma

The Journal of Allergy and Clinical Immunology
N PapageorgiouA B Kay

Abstract

Four subjects with clinical histories of milk-induced asthma were studied (three allergic to cow's milk; one to soya milk). In each instance, skin prick tests, RAST (IgE and IgG4), the basophil histamine release, and serum precipitins, using appropriate milk extracts, were negative. After the ingestion of milk all the subjects developed a reproducible and dose-dependent increase in airflow limitation. Three patients (two allergic to cow's milk; one to soya milk) gave a characteristic immediate-type reaction, which was maximal at 30 min after challenge. The fourth individual developed an isolated late-phase response, with maximal airways obstruction 3 hr after ingesting milk. In the three subjects who gave an early reaction, wheezing was accompanied by an elevation in circulating neutrophil chemotactic activity (NCA). This was not observed in the individual with the isolated late reaction. By Sephacryl S-400 gel-filtration chromatography it was shown that NCA of the early reactions eluted with proteins having an estimated molecular weight of 600,000 daltons. The immediate asthmatic response in peak expiratory flow rate and the elevation in NCA were inhibited by the prior oral administration of either disodium cromoglycate (DSCG)...Continue Reading

Citations

Aug 9, 1984·The New England Journal of Medicine·D D Metcalfe, M A Kaliner
Nov 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B R AdlerJ O Warner
Dec 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M H Lessof
May 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W TurnerS Strobel
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J O Warner
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards
Oct 1, 1987·Acta Paediatrica Japonica; Overseas Edition·T NagakuraT Otani

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