Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis

World Journal of Gastroenterology : WJG
Catherine M PastorJean-Louis Frossard

Abstract

To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis. Mice had cerulein administration to induce acute pancreatitis and were pretreated with either anti-mouse neutrophil serum or gadolinium chloride (GdCl3) to prevent Kupffer cell activation, or both treatments. Injury was assessed in pancreas and lungs. Myeloperoxidases (MPO) assessed neutrophil infiltration. Interleukin-6 (IL-6) and IL-10 were measured in serum, pancreas, lungs and liver. In mice with acute pancreatitis, neutrophil depletion reduced the severity of pancreatitis and pancreatitis-associated lung injury. Kupffer cell inactivation by GdCl3 had less protective effect, although IL-6 and IL-10 concentrations were significantly decreased. The protective treatment brought by neutrophil depletion was not enhanced by Kupffer cell inactivation and both treatments did not combine their protective effects. Our results confirm the role of activated neutrophils in aggravating organ injury in acute pancreatitis while the role of Kupffer cell activation is less obvious.

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Dec 11, 2003·Chest·Catherine M PastorJean-Louis Frossard

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Citations

Aug 8, 2006·Current Opinion in Gastroenterology·Stephen J Pandol
Oct 1, 2010·The British Journal of Surgery·A AbdullaH Thorlacius
Aug 4, 2011·Journal of Leukocyte Biology·Aree AbdullaSara Regnér
Nov 2, 2013·Pancreas·Ana C S CarvalhoMarcellus H L P de Souza
Sep 26, 2007·The Journal of Pathology·A VonlaufenJ L Frossard
Nov 19, 2010·Revista do Colégio Brasileiro de Cirurgiões·Diego da Fonseca MossmannAlessandro Bersch Osvaldt
Nov 24, 2011·The British Journal of Surgery·H HartmanS Regnér
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Sabrina Gea-Sorlí, Daniel Closa
Nov 18, 2014·International Journal of Experimental Pathology·Dietmar ZechnerBrigitte Vollmar
Oct 27, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Andreas M LenzWilliam G Cheadle
Aug 30, 2014·World Journal of Gastroenterology : WJG·Kristin S InmanNicole R Murray
Apr 14, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·A TurunenT Sorsa
Jun 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yi SongXiaoguang Lu
Sep 18, 2017·Gastroenterology·Anna S GukovskayaAida Habtezion

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