Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice

Endocrine
Rongying OuYunsheng Xu

Abstract

Non-alcoholic fatty liver disease is highly associated with morbidity and mortality in population. Although studies have already demonstrated that the immune response plays a pivotal role in the development of non-alcoholic fatty liver disease, the comprehensive regulation is unclear. Therefore, present study was carried out to investigate the non-alcoholic fatty liver disease development under neutrophil depletion. To achieve the aim of the study, C57BL/6 J mice were fed with high fat diet for 6 weeks before treated with neutrophil deplete antibody 1A8 or isotype control (200 μg/ mouse every week) for another 4 weeks. Treated with 1A8 antibody, obese mice exhibited better whole body metabolic parameters, including reduction of body weight gain and fasting blood glucose levels. Neutrophil depletion also effectively reduced hepatic structural disorders, dysfunction and lipid accumulation. Lipid β-oxidative markers, phosphorylated-AMP-activated protein kinase α and phosphorylated-acetyl-CoA carboxylase levels were increased in 1A8 antibody-treated obese mouse group. The mitochondrial number and function were also reversed after 1A8 antibody treatment, including increased mitochondrial number, reduced lipid oxidative damage and en...Continue Reading

References

Jan 1, 1996·Methods in Enzymology·G HofhausG Attardi
Apr 18, 1998·Gastroenterology·C P Day, O F James
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Aug 30, 2000·Pediatric Neurology·M A SelakE M Kaye
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Peter L M Jansen
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paola FilipazziLicia Rivoltini
Sep 22, 2007·Journal of Leukocyte Biology·Jean M DaleyJorge E Albina
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Dec 18, 2009·Nature Immunology·Kajsa Wing, Shimon Sakaguchi
Sep 21, 2011·Atherosclerosis·Veerle BieghsRonit Shiri-Sverdlov
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Naim AlkhouriAriel E Feldstein
Mar 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kouichi MiuraEkihiro Seki
Aug 7, 2012·Nature Medicine·Saswata TalukdarJerrold M Olefsky
Mar 9, 2013·Frontiers of Medicine·Jianping Ye
Sep 28, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Anna CarobeneWilliam A Bartlett
Jan 21, 2014·Toxicology and Applied Pharmacology·C David WilliamsHartmut Jaeschke
Mar 19, 2014·Cellular & Molecular Immunology·Ruonan XuFu-Sheng Wang
May 6, 2014·The Lancet. Diabetes & Endocrinology·Aiko P J de VriesUNKNOWN ERA-EDTA Working Group Diabesity
May 20, 2014·International Journal of Molecular Sciences·Fatiha Nassir, Jamal A Ibdah
Jul 21, 2015·Cell Metabolism·Xudong FuJing Huang

❮ Previous
Next ❯

Citations

Oct 17, 2018·Journal of Cellular and Molecular Medicine·Hezhongrong NieYiwen Zhou
May 10, 2019·Frontiers in Immunology·Chris John WestonDavid H Adams
Jan 18, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jingjing CaiHongliang Li
Nov 8, 2020·Cellular & Molecular Immunology·Kai LiuRuonan Xu
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuwei ZhangChengfu Xu
May 8, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fanta BarrowXavier S Revelo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.